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Biomater. Res., 2024 Apr 15:28:0022 | https://doi.org/10.34133/bmr.0022
Size-Dependent Effect of Indocyanine Green Nanoimaging Agent for Metastatic Lymph Node Detection
Quoc-Viet Le1†, Sungtaek Kang2†, Jaeseong Lee2, Hyeseon Park2, Jeong Gil Sun2, Jaiwoo Lee3*, and Gayong Shim2*
1Faculty of Pharmacy, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
2School of Systems Biomedical Science and Integrative Institute of Basic Sciences, Soongsil University, Seoul 06978, Republic of Korea.
3College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.
*Corresponding authors: Jaiwoo Lee, Gayong Shim
†These authors contributed equally to this study
Abstract
Identification of metastatic lymph nodes is a crucial step in lymph node dissection to prevent further cancer spread and recurrence. However, the current limitations in metastatic lymph node detection often result in extensive resection of normal lymph nodes, leading to serious complications. The clinical application of indocyanine green (ICG) as a tool for lymph node detection is challenging because of its short plasma half-life and rapid light-induced decomposition and clearance. To overcome this limitation, we used polydopamine nanoparticles (PNs) as carriers for ICG and screened for the optimal particle size for detecting metastatic lymph nodes. ICG/PNs with sizes of 80, 160, 300, and 600 nm were synthesized, and their ICG loading efficiency, physical stability, and lymph node distribution were evaluated. The ICG absorbed on the PNs was found to be protected from light degradation, and its retention at the lymph nodes was improved. Notably, the ICG/PNs favored the fluorescence signal at the metastatic lymph nodes compared to the nonmetastatic lymph nodes. Among the tested particle sizes, the 80-nm ICG/PN showed a higher distribution in the metastatic lymph nodes. This study suggests that the 80-nm ICG/PN is a potentially valuable reagent for the detection and diagnosis of lymph node metastasis.
논문정보
- Research article
- 2024년 04월 (BRIC 등록일 2024-04-18)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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