김수민 (연세대학교) | 한빛사논문 > 한빛사

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조회324

김수민Su Min Kim

연세대학교

EBioMedicine, Volume 103, May 2024, 105121 | https://doi.org/10.1016/j.ebiom.2024.105121 Biomarkers for phenotype-endotype relationship in atopic dermatitis: a critical review

Chang Ook Park ^a,c, Su Min Kim ^a,c, Kwang Hoon Lee ^a,d, Thomas Bieber ^b,d

^aDepartment of Dermatology & Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, South Korea

^bChristine Kühne-Center of Allergy Research and Education, Medicine Campus, Davos, Switzerland

^cThese authors contributed equally to this work.

^dThese authors share senior authorship.

Corresponding author : Chang Ook Park

Abstract

Atopic dermatitis (AD) is the most common form of chronic skin inflammation with diverse clinical variants. Historically, various AD phenotypes have been grouped together without considering their heterogeneity. This approach has resulted in a lack of phenotype- and endotype-adapted therapeutic strategies. Comprehensive insights into AD pathogenesis have enabled precise medicinal approach for AD. These efforts aimed to redefine the endophenotype of AD and develop various biomarkers for diverse purposes. Among these endeavours, efforts are underway to elucidate the mechanisms (and related biomarkers) that lead to the emergence and progression of atopic diseases originating from AD (e.g., atopic march). This review focuses on diverse AD phenotypes and calls for a definition of endophenotypes. While awaiting scientific validation, these biomarkers ensure predicting disease onset and trajectory and tailoring therapeutic strategies for the future.

논문정보

형식Review Paper
게재일2024년 05월 (BRIC 등록일 2024-04-16)
연구진국내(교신)+국외 연구진
분야 의약학 > 응용의학

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