Tamrin Chowdhury (서울대학교 의과대학) | 한빛사논문 > 한빛사

한빛사논문

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서울대학교 의과대학

Exp. Mol. Med., Apr 12 2024, | https://doi.org/10.1038/s12276-024-01204-3 Central neurocytoma exhibits radial glial cell signatures with FGFR3 hypomethylation and overexpression

Yeajina Lee ^1,2,11, Tamrin Chowdhury^3,11, Sojin Kim ³, Hyeon Jong Yu ³, Kyung-Min Kim ³, Ho Kang³, Min-Sung Kim ³, Jin Wook Kim ³, Yong-Hwy Kim ³, So Young Ji ⁴, Kihwan Hwang ⁴, Jung Ho Han ⁴, Jinha Hwang ⁵, Seong-Keun Yoo ⁶, Kyu Sang Lee ⁷, Gheeyoung Choe ⁷, Jae-Kyung Won ⁸, Sung-Hye Park ⁸, Yong Kyu Lee ⁹, Joo Heon Shin ^9,10, Chul-Kee Park^2,3,*, Chae-Yong Kim ^4,* and Jong-Il Kim ^1,2,*

¹Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Republic of Korea.
²Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Republic of Korea.
³Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
⁴Department of Neurosurgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.
⁵Department of Laboratory Medicine, Korea University Anam Hospital, Seoul, Republic of Korea.
⁶The Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
⁷Department of Pathology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Republic of Korea.
⁸Department of Pathology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
⁹Lieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD 21205, USA.
¹⁰Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
¹¹These authors contributed equally: Yeajina Lee, Tamrin Chowdhury.

^*Corresponding authors: correspondence to Chul-Kee Park, Chae-Yong Kim or Jong-Il Kim

Abstract

We explored the genomic events underlying central neurocytoma (CN), a rare neoplasm of the central nervous system, via multiomics approaches, including whole-exome sequencing, bulk and single-nuclei RNA sequencing, and methylation sequencing. We identified FGFR3 hypomethylation leading to FGFR3 overexpression as a major event in the ontogeny of CN that affects crucial downstream events, such as aberrant PI3K-AKT activity and neuronal development pathways. Furthermore, we found similarities between CN and radial glial cells based on analyses of gene markers and CN tumor cells and postulate that CN tumorigenesis is due to dysregulation of radial glial cell differentiation into neurons. Our data demonstrate the potential role of FGFR3 as one of the leading drivers of tumorigenesis in CN.

논문정보

형식Research article
게재일2024년 04월 (BRIC 등록일 2024-04-17)
연구진국내(교신)+국외 연구진
분야 의약학 > 종양의학

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