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연세대학교 의과대학

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Clin. Nucl. Med., Apr 08 2024, | https://doi.org/10.1097/RLU.0000000000005211 Hypoperfusion in Alzheimer's Disease-Prone Regions and Dementia Conversion in Parkinson's Disease

Chun, Min Young MD, PhD^∗,†,‡; Lee, Taein BA^§,∥; Kim, Su Hong MD, PhD^§,∥,¶; Lee, Hye Sun PhD^∗∗; Kim, Yun Joong MD, PhD^∗,†,‡; Lee, Phil Hyu MD, PhD^∗; Sohn, Young H. MD, PhD^∗; Jeong, Yong MD, PhD^{§,∥,††,‡‡}; Chung, Seok Jong MD, PhD^∗,†,‡

From the ^∗Department of Neurology, Yonsei University College of Medicine, Seoul, South Korea

^†Department of Neurology, Yongin Severance Hospital, Yonsei University Health System, Yongin, South Korea

^‡Yonsei Beyond Lab, Yongin, South Korea

^§Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea

^∥KAIST Institute for Health Science Technology, Korea Advanced Institute of Science and Technology, Daejeon, South Korea

^¶Department of Radiology, Yeungnam University College of Medicine, Gyeongsan, South Korea

^∗∗Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, South Korea

^††Program of Brain and Cognitive Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea

^‡‡Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea.

Min Young Chun and Taein Lee contributed equally to this work and share first authorship.

Yong Jeong and Seok Jong Chung contributed equally to this article as co–senior authors.

Correspondence to: Seok Jong Chung, MD, PhD, Yong Jeong, MD, PhD

Abstract

Although early detection of individuals at risk of dementia conversion is important in patients with Parkinson's disease (PD), there is still no consensus on neuroimaging biomarkers for predicting future cognitive decline. We aimed to investigate whether cerebral perfusion patterns on early-phase 18F-N-(3-fluoropropyl)-2β-carboxymethoxy-3β-(4-iodophenyl) nortropane (18F-FP-CIT) PET have the potential to serve as a neuroimaging predictor for early dementia conversion in patients with PD. In this retrospective analysis, we enrolled 187 patients with newly diagnosed PD who underwent dual-phase 18F-FP-CIT PET at initial assessment and serial cognitive assessments during the follow-up period (>5 years). Patients with PD were classified into 2 groups: the PD with dementia (PDD)-high-risk (PDD-H; n = 47) and the PDD-low-risk (PDD-L; n = 140) groups according to dementia conversion within 5 years of PD diagnosis. We explored between-group differences in the regional uptake in the early-phase 18F-FP-CIT PET images. We additionally performed a linear discriminant analysis to develop a prediction model for early PDD conversion. The PDD-H group exhibited hypoperfusion in Alzheimer's disease (AD)-prone regions (inferomedial temporal and posterior cingulate cortices, and insula) compared with the PDD-L group. A prediction model using regional uptake in the right entorhinal cortex, left amygdala, and left isthmus cingulate cortex could optimally distinguish the PDD-H group from the PDD-L group. Regional hypoperfusion in the AD-prone regions on early-phase 18F-FP-CIT PET can be a useful biomarker for predicting early dementia conversion in patients with PD.

논문정보

형식Research article
게재일2024년 04월 (BRIC 등록일 2024-04-18)
연구진국내 연구진
분야 바이오·의료융합 > 뇌인지과학

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