최진수 (안전성평가연구소) | 한빛사논문 > 한빛사

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조회238

최진수Jin Soo Choi

안전성평가연구소

J. Hazard. Mater., Volume 470, 15 May 2024, 134209 | https://doi.org/10.1016/j.jhazmat.2024.134209 Comparison of gut toxicity and microbiome effects in zebrafish exposed to polypropylene microplastics: Interesting effects of UV-weathering on microbiome

Jin Soo Choi ^a, Hakwon Yoon ^b, Yunwi Heo ^a, Tae Hee Kim ^c, June-Woo Park ^a,d

^aEnvironmental Exposure & Toxicology Research Center, Korea Institute of Toxicology, 17 Jegok-gil, Jinju 52834, Republic of Korea

^bDepartment of Biological Enivronment, Kangwon National University, Chuncheon 24341, Republic of Korea

^cAdvanced Textile R&D Department, Korea Institute of Industrial Technology, Ansan 426-171, Republic of Korea

^dHuman and Environmental Toxicology Program, Korea University of Science and Technology (UST), 217, Gajeong-ro, Daejeon 34113, Republic of Korea

Corresponding author: June-Woo Park

Abstract

Weathered microplastics (MPs) exhibit different physicochemical properties compared to pristine MPs, thus, their effects on the environment and living organisms may also differ. In the present study, we investigated the gut-toxic effects of virgin polypropylene MPs (PP) and UV-weathered PP MPs (UV-PP) on zebrafish. The zebrafish were exposed to the two types of PP MPs at a concentration of 50 mg/L each for 14 days. After exposure, MPs accumulated primarily within the gastrointestinal tract, with UV-PP exhibiting a higher accumulation than PP. The ingestion of PP and UV-PP induced gut damage in zebrafish and increased the gene expression and levels of enzymes related to oxidative stress and inflammation, with no significant differences between the two MPs. Analysis of the microbial community confirmed alterations in the abundance and diversity of zebrafish gut microorganisms in the PP and UV-PP groups, with more pronounced changes in the PP-exposed group. Moreover, the Kyoto Encyclopedia of Genes and Genomes pathway analysis confirmed the association between changes in the gut microorganisms at the phylum and genus levels with cellular responses, such as oxidative stress, inflammation, and tissue damage. This study provides valuable insights regarding the environmental impact of MPs on organisms.

논문정보

형식Research article
게재일2024년 05월 (BRIC 등록일 2024-04-18)
연구진국내 연구진
분야 생명과학 > 분류/생태/환경생물학

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