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Biosens. Bioelectron., Apr 02 2024, 255 S0956-5663(24)00272-0 | https://doi.org/10.1016/j.bios.2024.116267 Flexible low-profile external ventricular drain catheter for real-time brain monitoring

Hoon Yi^a,b, Hodam Kim^a,b, Ka Ram Kim ^a,b, Ju Hyeon Kim ^a,b,c, Juhee Kim^d, Hyunjae Lee ^e, Sanjeet S. Grewal ^f, William D. Freeman ^f,g, Woon-Hong Yeo^a,b,h

^aGeorge W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA

^bIEN Center for Wearable Intelligent Systems and Healthcare Institute for Electronics and Nanotechnology, Georgia Institute of Technology, Atlanta, GA, 30332, USA

^cDepartment of Mechanical Engineering, Inha University, Incheon, 22212, Republic of Korea

^dDepartment of Mechanical System Engineering, Korea Military Academy, Seoul, 01805, Republic of Korea

^eDepartment of Mechanical Engineering, Korea University, Seoul, 02841, Republic of Korea

^fDepartment of Neurosurgery, Mayo Clinic, Jacksonville, FL, 32224, USA

^gDepartment of Neurology, Department of Critical Care Medicine, Mayo Clinic, Jacksonville, FL, 32224, USA

^hWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, GA, 30332, USA

Corresponding author: Woon-Hong Yeo

Abstract

External ventricular drainage is one of the most common neurosurgical procedures in the world for acute hydrocephalus, which must be performed carefully by a neurosurgeon. Although various neuromonitoring external ventricular drain (EVD) catheters have been utilized, they still suffer from rigidity and bulkiness to mitigate post-EVD placement trauma. Here, we introduce a flexible and low-profile smart EVD catheter using a class of technologies with sensitive electrical materials, seamless integration, and flexible mechanics, which serves as a highly soft and minimally invasive device to monitor electrical brain signals. This device reliably captures biopotentials in real time while exhibiting remarkable flexibility and reliability. The seamless integration of its sensory system promises a minimally invasive EVD placement on brain tissue. This work validates the device's distinct characteristics and performances through in vitro experiments and computational analysis. Collectively, this device's exceptional patient- and user-friendly attributes highlight its potential as one of the most practical EVD catheters.

논문정보

형식Research article
게재일2024년 04월 (BRIC 등록일 2024-04-09)
연구진국외 연구진
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