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Indiana University

Neuron, Apr 03 2024, 112 (7) S0896-6273(24)00157-0 | https://doi.org/10.1016/j.neuron.2024.03.003 APOE loss of function: A genetic shield against Alzheimer's disease

Mason D. Tate ^1,2, Hande Karahan^1,3, Jungsu Kim ^1,2,3

¹Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA

²Medical Neuroscience Graduate Program, Indiana University School of Medicine, Indianapolis, IN, USA

³Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA

Corresponding author : Jungsu Kim

Abstract

In this issue of Neuron, Chemparathy et al. ¹ provide human genetics data suggesting that APOE loss-of-function mutations may confer resistance to Alzheimer's disease (AD) without compromising longevity. These data strongly support the APOE toxic gain-of-function hypothesis for AD.

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게재일2024년 04월 (BRIC 등록일 2024-04-08)
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분야 생명과학 > 신경생물학

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