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University of Texas MD Anderson Cancer Center

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Cancer Discov., Apr 04 2024, 14 (4) | https://doi.org/10.1158/2159-8290.CD-23-1550 The Hallmarks of Precancer

Mary M. Stangis^#,1,2,3, Zhengyi Chen ^#,4,5, Jimin Min ^#,6,7, Sarah E. Glass ^#,5,8, Jordan O. Jackson ^#,9,10, Megan D. Radyk ^#,11, Xen Ping Hoi ^12,13, W. Nathaniel Brennen ^14,15,16, Ming Yu ^10,17,18, Huy Q. Dinh ^1,19, Robert J. Coffe^{y 5,8,20,21}, Martha J. Shrubsole ^21,22, Keith S. Chan ^12,13, William M. Grady ^10,17,18, Srinivasan Yegnasubramanian^14,23,24,25, Costas A Lyssiotis ^11,26,27, Anirban Maitra ^6,7, Richard B. Halberg^1,2,3, Neelendu Dey ^10,17, Ken S. Lau ^4,5,8,21,28

¹McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin-Madison, Madison, Wisconsin.

²Gastroenterology Division, Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin.

³Carbone Cancer Center, University of Wisconsin-Madison, Madison, Wisconsin.

⁴Chemical and Physical Biology Program, Vanderbilt University School of Medicine, Nashville, Tennessee.

⁵Epithelial Biology Center, Vanderbilt University Medical Center, Nashville, Tennessee.

⁶Department of Translational Molecular Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas.

⁷Sheikh Ahmed Center for Pancreatic Cancer Research, University of Texas MD Anderson Cancer Center, Houston, Texas.

⁸Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee.

⁹Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington.

¹⁰Translational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, Washington.

¹¹Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, Michigan.

¹²Department of Urology, Houston Methodist Research Institute, Houston, Texas.

¹³Neal Cancer Center, Houston Methodist Research Institute, Houston, Texas.

¹⁴Genitourinary Cancer Disease Division, Department of Oncology, Johns Hopkins Medicine, Baltimore, Maryland.

¹⁵Department of Pharmacology and Molecular Sciences, Johns Hopkins Medicine, Baltimore, Maryland.

¹⁶Department of Urology, Johns Hopkins Medicine, Baltimore, Maryland.

¹⁷Division of Gastroenterology, Department of Medicine, University of Washington, Seattle, Washington.

¹⁸Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington.

¹⁹Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin.

²⁰Division of Gastroenterology, Hepatology, & Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

²¹Vanderbilt-Ingram Cancer Center, Nashville, Tennessee.

²²Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

²³Molecular Radiation Science Division, Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins Medicine, Baltimore, Maryland.

²⁴Kidney-Urologic Pathology Division, Department of Pathology, Johns Hopkins Medicine, Baltimore, Maryland.

²⁵Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins Medicine, Baltimore, Maryland.

²⁶Division of Gastroenterology, Internal Medicine, University of Washington, Seattle, Washington.

²⁷Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan.

²⁸Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee.

^#Contributed equally.

Corresponding Authors: Neelendu Dey, and Ken S. Lau

Abstract

Research on precancers, as defined as at-risk tissues and early lesions, is of high significance given the effectiveness of early intervention. We discuss the need for risk stratification to prevent overtreatment, an emphasis on the role of genetic and epigenetic aging when considering risk, and the importance of integrating macroenvironmental risk factors with molecules and cells in lesions and at-risk normal tissues for developing effective intervention and health policy strategies.

논문정보

형식Research article
게재일2024년 04월 (BRIC 등록일 2024-04-08)
연구진국외 연구진
분야 생명과학 > 노화/암생물학

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