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Adv. Healthc. Mater., Apr 04 2024, | https://doi.org/10.1002/adhm.202302682
Investigation of the Dysfunction Caused by High Glucose, Advanced Glycation End Products, and Interleukin-1 Beta and the Effects of Therapeutic Agents on the Microphysiological Artery Model
Ungsig Nam1,4, Jaesang Kim1, Hee-gyeong Yi2,3 and Jessie S. Jeon1*
1Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea
2Department of Convergence Biosystems Engineering, Chonnam National University, Gwangju 61186, Republic of Korea
3Interdisciplinary Program in IT-Bio Convergence System, Chonnam National University
4Center for Scientific Instrumentation, Korea Basic Science Institute (KBSI), Daejeon, 34133, Republic of Korea
*CORRESPONDING AUTHOR : Jessie S. Jeon
Abstract
Diabetes mellitus has substantial global implications and contributes to vascular inflammation and the onset of atherosclerotic cardiovascular diseases. However, translating the findings from animal models to humans has inherent limitations, necessitating a novel platform. Therefore, herein, we established an arterial model using a microphysiological system. This model successfully replicated the stratified characteristics of human arteries by integrating collagen, endothelial cells (ECs), and vascular smooth muscle cells. Perfusion via a peristaltic pump showed dynamic characteristics distinct from those of static culture models. High glucose, advanced glycation end products (AGEs), and interleukin-1 beta were employed to stimulate diabetic conditions, resulting in notable cellular changes and different levels of cytokines and nitric oxide. Additionally, the interactions between the disease models and oxidized low-density lipoproteins were examined. Finally, we investigated the potential therapeutic effects of metformin, atorvastatin, and diphenyleneiodonium. Metformin and diphenyleneiodonium mitigated high-glucose- and AGE-associated pathological changes, whereas atorvastatin affected only the morphology of ECs. Altogether, our arterial model represents a pivotal advancement, offering a robust and insightful platform for investigating cardiovascular diseases and their corresponding drug development. This article is protected by copyright. All rights reserved.
논문정보
- Research article
- 2024년 04월 (BRIC 등록일 2024-04-11)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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