한빛사논문
- 조회393
Su Youn Nam 1,2,*, Junwoo Jo 3 & Chang-Min Cho 1,2
1Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, South Korea.
2Division of Gastroenterology, Kyungpook National University Chilgok Hospital, Daegu, South Korea.
3Department of Statistics, Kyungpook National University, Daegu, South Korea.
*Corresponding author: correspondence to Su Youn Nam
Abstract
High-density Lipoprotein Cholesterol (HDL-C) levels have been associated with cancer. In this observational population-based cohort study using data from the Korean National Health Insurance Service system, we investigate the impact of longitudinal changes in HDL-C levels on gastrointestinal cancer risk. Individuals who underwent health examinations in 2010 and 2014 were followed-up through 2021. Among 3.131 million, 40696 gastric, 35707 colorectal, 21309 liver, 11532 pancreatic, 4225 gallbladder, and 7051 biliary cancers are newly detected. The persistent low HDL-C group increases the risk of gastric, liver, and biliary cancer comparing to persistent normal HDL-C group. HDL-C change from normal to low level increases the risk for gastric, colorectal, liver, pancreatic, gallbladder, and biliary cancers. Effects of HDL-C change on the gastrointestinal cancer risk are also modified by sex and smoking status. HDL-C changes affect the gastric and gallbladder cancer risk in age ≥60 years and the pancreatic and biliary cancer risk in age <60 years. Here, we show persistently low HDL-C and normal-to-low HDL-C change increase gastrointestinal cancer risk with discrepancies by sex, smoking status, and age.
논문정보
- Research article
- 2024년 04월 (BRIC 등록일 2024-04-05)
- 국내 연구진
- 의약학 > 종양의학
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