안병선 (UNIST, 현 LG에너지솔루션)

한빛사논문

조회263

안병선David B. Ahn

UNIST, 현 LG에너지솔루션

Sci. Adv., Apr 05 2024, 10 (14) | https://doi.org/10.1126/sciadv.adn3784 Power-integrated, wireless neural recording systems on the cranium using a direct printing method for deep-brain analysis

Yong Won Kwon ^{1 2} ^†, David B Ahn ^3 †, Young-Geun Park^{1 2 †}, Enji Kim ^{1 2}, Dong Ha Lee ^{1 2}, Sang-Woo Kim³, Kwon-Hyung Lee ⁴, Won-Yeong Kim ⁵, Yeon-Mi Hong^{1 2}, Chin Su Koh ⁶, Hyun Ho Jung ⁶, Jin Woo Chang ⁷, Sang-Young Lee ^{5 *}, Jang-Ung Park ^{1 2 6 8 *}

¹Department of Materials Science and Engineering, Yonsei University, Seoul 03722, Republic of Korea.

²Center for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea.

³Department of Energy and Chemical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.

⁴Ulsan Advanced Energy Technology R&D Center, Korea Institute of Energy Research (KIER), Ulsan 44776, Republic of Korea.

⁵Department of Chemical and Biomolecular Engineering, Yonsei University, Seoul 03772, Republic of Korea.

⁶Department of Neurosurgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

⁷Department of Neurosurgery, Korea University Anam Hospital, Seoul 02841, Republic of Korea.

⁸Graduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul 03722, Republic of Korea.

^†These authors contributed equally
^*Corresponding authors: correspondence to Sang-Young Lee or Jang-Ung Park

Abstract

Conventional power-integrated wireless neural recording devices suffer from bulky, rigid batteries in head-mounted configurations, hindering the precise interpretation of the subject's natural behaviors. These power sources also pose risks of material leakage and overheating. We present the direct printing of a power-integrated wireless neural recording system that seamlessly conforms to the cranium. A quasi-solid-state Zn-ion microbattery was 3D-printed as a built-in power source geometrically synchronized to the shape of a mouse skull. Soft deep-brain neural probes, interconnections, and auxiliary electronics were also printed using liquid metals on the cranium with high resolutions. In vivo studies using mice demonstrated the reliability and biocompatibility of this wireless neural recording system, enabling the monitoring of neural activities across extensive brain regions without notable heat generation. This all-printed neural interface system revolutionizes brain research, providing bio-conformable, customizable configurations for improved data quality and naturalistic experimentation.

논문정보

형식Research article
게재일2024년 04월 (BRIC 등록일 2024-04-04)
연구진국내 연구진
분야 바이오·의료융합 > 뇌인지과학

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