한빛사논문
- 조회387
Nakwon Kwak 1,2, Emily Henkle 3, Hyeontaek Hwang 4, Doosoo Jeon 5, Byung Woo Jhun 6, Kyung-Wook Jo 7, Young Ae Kang 8, Hyung-Jun Kim 2,9, Joong-Yub Kim 1,2, Young Ran Kim 10, Yong-Soo Kwon 11, Jae Ho Lee 2,9, Jeongha Mok 12, Youngmok Park 8, Tae Sun Shim 7, Hojoon Sohn 13, Jake Whang 14, Jae-Joon Yim 1,2
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, South Korea.
2Department of Internal Medicine, Seoul National University, Seoul National University College of Medicine, Seoul, South Korea.
3OHSU-PSU School of Public Health, Portland, Oregon, USA.
4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul, South Korea.
5Department of Internal Medicine, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan, South Korea.
6Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Centre, Sungkyunkwan University School of Medicine, Seoul, South Korea.
7Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.
8Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
9Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
10Division of Clinical Research, International Tuberculosis Research Centre, Seoul, South Korea.
11Department of Internal Medicine, Chonnam National University Hospital, Gwangju, South Korea.
12Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea.
13Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, South Korea.
14Korea Mycobacterium Resource Center and Basic Research Section, The Korean Institute of Tuberculosis, Cheongju, South Korea.
Correspondence: J.-J. Yim
Abstract
Background
Improving health-related quality of life (HRQOL) has emerged as a priority in the management of nontuberculous mycobacterial pulmonary disease (NTM-PD). We aimed to evaluate HRQOL and its changes after 6 months’ treatment in patients with NTM-PD.
Methods
The NTM-KOREA is a nationwide prospective cohort enrolling patients initiating treatment for NTM-PD in 8 institutions across South Korea. We conducted the Quality of Life–Bronchiectasis (QOL-B) at 6-month intervals and evaluated baseline scores (higher scores indicate better quality of life) and changes after 6 months’ treatment. Multivariate logistic regression was performed to identify factors associated with improvement in the QOL-B physical functioning and respiratory symptoms domains.
Results
Between February 2022 and August 2023, 411 patients were included in the analysis. Baseline scores (95% confidence interval [CI]) for physical functioning and respiratory symptoms were 66.7 (46.7–86.7) and 81.5 (70.4–92.6), respectively. Among 228 patients who completed the QOL-B after 6 months’ treatment, improvements in physical functioning and respiratory symptoms were observed in 61 (26.8%) and 71 (31.1%) patients, respectively. A lower score (adjusted odds ratio; 95% CI) for physical functioning (0.93; 0.91–0.96) and respiratory symptoms (0.92; 0.89–0.95) at treatment initiation was associated with a greater likelihood of physical functioning and respiratory symptom improvement, respectively; achieving culture conversion was not associated with improvement in physical functioning (0.62; 0.28–1.39) or respiratory symptoms (1.30; 0.62–2.74).
Conclusions
After 6 months of antibiotic treatment for NTM-PD, HRQOL improved in almost one-third, especially in patients with severe initial symptoms, regardless of culture conversion.
논문정보
- Research article
- 2024년 04월 (BRIC 등록일 2024-04-04)
- 국내(교신)+국외 연구진
- 의약학 > 응용의학
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