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Nat. Immunol., Apr 02 2024, | https://doi.org/10.1038/s41590-024-01797-x
Prenatal and postnatal neuroimmune interactions in neurodevelopmental disorders
Eunha Kim 1,2,*, Jun R. Huh 3 & Gloria B. Choi 4,*
1BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.
2Department of Neuroscience, Korea University College of Medicine, Seoul, Republic of Korea.
3Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
4The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA.
*Corresponding authors: correspondence to Eunha Kim or Gloria B. Choi
Abstract
The intricate relationship between immune dysregulation and neurodevelopmental disorders (NDDs) has been observed across the stages of both prenatal and postnatal development. In this Review, we provide a comprehensive overview of various maternal immune conditions, ranging from infections to chronic inflammatory conditions, that impact the neurodevelopment of the fetus during pregnancy. Furthermore, we examine the presence of immunological phenotypes, such as immune-related markers and coexisting immunological disorders, in individuals with NDDs. By delving into these findings, we shed light on the potential underlying mechanisms responsible for the high occurrence of immune dysregulation alongside NDDs. We also discuss current mouse models of NDDs and their contributions to our understanding of the immune mechanisms underlying these diseases. Additionally, we discuss how neuroimmune interactions contribute to shaping the manifestation of neurological phenotypes in individuals with NDDs while also exploring potential avenues for mitigating these effects.
논문정보
- Review Paper
- 2024년 04월 (BRIC 등록일 2024-04-03)
- 국내(교신)+국외 연구진
- 의약학 > 면역의학
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