한빛사논문
- 조회240
Sunghoon Kim 1,2,3,8, Donghyuk Lee 4,8, Sung Eun Kim 1,2,3,* and Michael Overholtzer 5,6,7,*
1Department of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul, Republic of Korea.
2Department of Integrated Biomedical and Life Sciences, College of Health Sciences, Korea University, Seoul, Republic of Korea.
3L-HOPE Program for Community-Based Total Learning Health Systems, Seoul, Republic of Korea.
4Department of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.
5Cell Biology Program, Sloan Kettering Institute for Cancer Research, New York, NY, USA.
6Louis V. Gerstner, Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
7BCMB Allied Program, Weill Cornell Medical College, New York, NY, USA.
8These authors contributed equally: Sunghoon Kim, Donghyuk Lee.
*Corresponding authors: correspondence to Sung Eun Kim or Michael Overholtzer
Abstract
Cell death pathways play critical roles in organism development and homeostasis as well as in the pathogenesis of various diseases. While studies over the last decade have elucidated numerous different forms of cell death that can eliminate cells in various contexts, how certain mechanisms impact physiology is still not well understood. Moreover, recent studies have shown that multiple forms cell death can occur in a cell population, with different forms of death eliminating individual cells. Here, we aim to describe the known molecular mechanisms of entosis, a non-apoptotic cell engulfment process, and discuss signaling mechanisms that control its induction as well as its possible crosstalk with other cell death mechanisms.
논문정보
- Review Paper
- 2024년 02월 (BRIC 등록일 2024-04-08)
- 국내(교신)+국외 연구진
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