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Pharmacol. Ther. , Mar 26 2024, S0163-7258(24)00058-5 | https://doi.org/10.1016/j.pharmthera.2024.108638
Epigenetic determinants and non-myocardial signaling pathways contributing to heart growth and regeneration
Jihyun Jang a,b, Federica Accornero c, Deqiang Li a,b
aCenter for Cardiovascular Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH 43215, USA
bDepartment of Pediatrics, The Ohio State University College of Medicine, Columbus, OH 43215, USA
cDepartment of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA
Corresponding authors : Jihyun Jang, Deqiang Li
Abstract
Congenital heart disease is the most common birth defect worldwide. Defective cardiac myogenesis is either a major presentation or associated with many types of congenital heart disease. Non-myocardial tissues, including endocardium and epicardium, function as a supporting hub for myocardial growth and maturation during heart development. Recent research findings suggest an emerging role of epigenetics in nonmyocytes supporting myocardial development. Understanding how growth signaling pathways in non-myocardial tissues are regulated by epigenetic factors will likely identify new disease mechanisms for congenital heart diseases and shed lights for novel therapeutic strategies for heart regeneration.
논문정보
- Review Paper
- 2024년 03월 (BRIC 등록일 2024-04-02)
- 국외 연구진
- 생명과학 > 발생생물학
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