한빛사논문
- 조회481
Woojin Jeon 1#, Jae Myeong Lee 2,3#, Yeji Kim 1#, Yunheum Lee 1#, Joonhee Won 4, Somin Lee 4, Wonkyeong Son 5, Yong Hoe Koo 6, Ji-Won Hong 4, Hocheol Gwac 3, Jinmyoung Joo 6, Seon Jeong Kim 3, Changsoon Choi 2*, Seongjun Park 1,7,8*
1Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
2Department of Electronic Engineering and Biomedical Engineering, Hanyang University, Seoul, 04763, South Korea.
3Center for Self-Powered Actuation, Department of Electronic Engineering and Biomedical Engineering, Hanyang University, Seoul, 04763, South Korea.
4Program of Brain and Cognitive Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
5Department of Energy Science, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
6Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, 44919, Republic of Korea.
7Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, 34141, Republic of Korea.
8KAIST Institute for NanoCentury (KINC), Daejeon, 34141, Republic of Korea.
#W. Jeon., J. M. Lee, Y. Kim, and Y. Lee contributed equally to this work.
*CORRESPONDING AUTHORS : Changsoon Choi, Seongjun Park
Abstract
Neural probe engineering is a dynamic field, driving innovation in neuroscience and addressing scientific and medical demands. Recent advancements involve integrating nanomaterials to improve performance, aiming for sustained in vivo functionality. However, challenges persist due to size, stiffness, complexity, and manufacturing intricacies. To address these issues, we propose a neural interface utilizing freestanding CNT-sheets drawn from CNT-forests integrated onto thermally drawn functional polymer fibers. This approach yields a device with structural alignment, resulting in exceptional electrical, mechanical, and electrochemical properties while retaining biocompatibility for prolonged periods of implantation. This Structurally Aligned Multifunctional neural Probe (SAMP) employing forest-drawn CNT sheets demonstrates in vivo capabilities in neural recording, neurotransmitter detection, and brain/spinal cord circuit manipulation via optogenetics, maintaining functionality for over a year post-implantation. The straightforward fabrication method's versatility, coupled with the device's functional reliability, underscores the significance of this technique in the next-generation carbon-based implants. Moreover, the device's longevity and multifunctionality positions it as a promising platform for long-term neuroscience research.
논문정보
- Research article
- 2024년 03월 (BRIC 등록일 2024-04-01)
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