Ramasubba Reddy Palem (동국대학교)

한빛사논문

조회171

Ramasubba Reddy PalemRamasubba Reddy Palem

동국대학교

Carbohydr. Polym., Available online 4 March 2024 | https://doi.org/10.1016/j.carbpol.2024.122020 In situ fabricated ZnO nanostructures within carboxymethyl cellulose-based ternary hydrogels for wound healing applications

Ramasubba Reddy Palem ^a, Byoung Ju Kim ^a, Inho Baek ^a, Hyejong Choi ^a, Maduru Suneetha ^b, Ganesh Shimoga ^c, Soo-Hong Lee ^a

^aDepartment of Biomedical Engineering, Dongguk University, Biomedical Campus 32, Gyeonggi 10326, Republic of Korea

^bSchool of Chemical Engineering, Yeungnam University, 280 Daehak-Ro, Gyeongsan 38541, Republic of Korea

^cDepartment of Biotechnology and Nanomedicine, SINTEF Industry, 7034 Trondheim, Norway

Corresponding author : Soo-Hong Lee

Abstract

Zinc oxide nanostructures (ZnO NS) were fabricated in situ within a ternary hydrogel system composed of carboxymethyl cellulose-agarose-polyvinylpyrrolidone (CAP@ZnO TNCHs) by a one-pot method employing moist-heat solution casting. The percentages of CMC and ZnO NS were varied in the CAP hydrogel films and then they were investigated by different techniques, such as ATR/FTIR, TGA, XRD, XPS, and FE-SEM analysis. Furthermore, the mechanical properties, hydrophilicity, swelling, porosity, and antibacterial activity of the CAP@ZnO TNCHs were studied. In-vitro biocompatibility assays were performed with skin fibroblast (CCD-986sk) cells. In-vitro culture of CCD-986sk fibroblasts showed that the ZnO NS facilitated cell adhesion and proliferation. Furthermore, the application of CAP@ZnO TNCHs enhanced cellular interactions and physico-chemical, antibacterial bacterial, and biological performance relative to unmodified CAP hydrogels. Also, an in vivo wound healing study verified that the CAP@ZnO TNCHs promoted wound healing significantly within 18 days, an effect superior to that of unmodified CAP hydrogels. Hence, these newly developed cellulose-based ZnO TNCHs are promising materials for wound healing applications.

논문정보

형식Research article
게재일2024년 03월 (BRIC 등록일 2024-04-15)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오소재

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