원동성 (울산대학교 의과대학, 서울아산병원) | 한빛사논문 > 한빛사

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조회385

원동성Dong-Sung Won

울산대학교 의과대학, 서울아산병원

CV File 265 kb

Bioact. Mater., 2024 Mar 21:37:172-190 | https://doi.org/10.1016/j.bioactmat.2024.03.018 3D-printed versatile biliary stents with nanoengineered surface for anti-hyperplasia and antibiofilm formation

Hyun Lee ^a,b,1, Dong-Sung Won ^c,1, Sinwoo Park^a,b, Yubeen Park ^c,d, Ji Won Kim ^c,d, Ginam Han^a,b, Yuhyun Na ^a,b, Min-Ho Kang ^a,b, Seok Beom Kim ^e, Heemin Kang^f, Jun-Kyu Park ^g, Tae-Sik Jang ^h, Sang Jin Leeⁱ, Su A. Park ^j, Sang Soo Lee^d, Jung-Hoon Park ^c,k, Hyun-Do Jung^l

^aDepartment of Biomedical-Chemical Engineering, The Catholic University of Korea, Bucheon, 14662, Gyeonggi-do, Republic of Korea

^bDepartment of Biotechnology, The Catholic University of Korea, Bucheon, 14662, Republic of Korea

^cBiomedical Engineering Research Center, Asan Institute for Life Sciences, Asan Medical Center, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea

^dDepartment of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, Republic of Korea

^eResearch Center, Metamorp Inc, Seoul, 08584, Republic of Korea

^fDepartment of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of Korea

^gIMT Inc, Gwangju, 61086, Republic of Korea

^hSchool of Biomedical Convergence Engineering, Pusan National University, Yangsan, 50612, Republic of Korea

ⁱBiofunctional Materials, Division of Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, 34 Hospital Road, Sai Ying Pun, Hong Kong SAR, PR China

^jNano-Convergence Manufacturing Systems Research Division, Korea Institute of Machinery and Materials (KIMM), Daejeon, 34103, Republic of Korea

^kDepartment of Convergence Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-Gil, Songpa-gu, Seoul, 05505, Republic of Korea

^lDivision of Materials Science and Engineering, Hanyang University, Seoul, 04763, Republic of Korea

¹Both authors contributed equally to this work.

Co-Corresponding authors : Jung-Hoon Park, Hyun-Do Jung

Abstract

Biliary strictures are characterized by the narrowing of the bile duct lumen, usually caused by surgical biliary injury, cancer, inflammation, and scarring from gallstones. Endoscopic stent placement is a well-established method for the management of biliary strictures. However, maintaining optimal mechanical properties of stents and designing surfaces that can prevent stent-induced tissue hyperplasia and biofilm formation are challenges in the fabrication of biodegradable biliary stents (BBSs) for customized treatment. This study proposes a novel approach to fabricating functionalized polymer BBSs with nanoengineered surfaces using 3D printing. The 3D printed stents, fabricated from bioactive silica poly(ε-carprolactone) (PCL) via a sol-gel method, exhibited tunable mechanical properties suitable for supporting the bile duct while ensuring biocompatibility. Furthermore, a nanoengineered surface layer was successfully created on a sirolimus (SRL)-coated functionalized PCL (fPCL) stent using Zn ion sputtering-based plasma immersion ion implantation (S-PIII) treatment to enhance the performance of the stent. The nanoengineered surface of the SRL-coated fPCL stent effectively reduced bacterial responses and remarkably inhibited fibroblast proliferation and initial burst release of SRL in vitro systems. The physicochemical properties and biological behaviors, including in vitro biocompatibility and in vivo therapeutic efficacy in the rabbit bile duct, of the Zn-SRL@fPCL stent demonstrated its potential as a versatile platform for clinical applications in bile duct tissue engineering.

논문정보

형식Research article
게재일2024년 03월 (BRIC 등록일 2024-04-01)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오소재

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