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장세림Se Rim Jang

전북대학교

Chem. Eng. J., Volume 487, 1 May 2024, 150757 | https://doi.org/10.1016/j.cej.2024.150757 Flower-like Ti(HPO4)2 bioceramic-laden 3D printed platform for enhanced bone regeneration via BMP signaling pathway

Il Won Suh ^a, Jeong In Kim ^b, Bishnu Kumar Shrestha ^c, Se Rim Jang ^d, Chan Hee Park^a,c,d

^aDepartment of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 561-756, Republic of Korea

^bDepartment of Orthopedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam-si, Gyeonggi-do 4630712, Republic of Korea

^cDepartment of Bionanosystem Engineering, Graduate School, Jeonbuk National University, Jeonju 561-756, Republic of Korea

^dDivision of Mechanical Design Engineering, College of Engineering, Jeonbuk National University, Jeonju 561-756, Republic of Korea

Corresponding authors : Se Rim Jang, Chan Hee Park

Abstract

Regenerative bone implants have been designed to promote new bone formation, however, the search for a suitable implant remains challenging despite the use of various biomaterials (e.g., bone cement, hydroxyapatite, allograft). In this study, we developed a highly bioactive flower-like titanium phosphate (Ti(HPO4)2) bioceramic and poly(ε-caprolactone) 3D composite with a hierarchical structure and interconnected pores. The newly synthesized Ti(HPO4)2 bioceramic, exhibiting an amorphous surface resembling native bone, high porosity, and enhanced ion release properties, was incorporated into 3D scaffolds using an optimized pneumatic 3D printing process. These scaffolds demonstrated their potential for bone regeneration by promoting early osteogenic differentiation and rapid mineralization with human bone marrow mesenchymal stem cells (hBM-MSCs). Moreover, it was revealed their structural stability and tissue regeneration effects after implantation in mouse calvaria. The developed 3D-printed PCL/Ti(HPO4)2 scaffold exhibited enhanced performance in bone regeneration and angiogenesis effects, activated by the bone morphogenetic protein (BMP) signaling pathway. Therefore, this study demonstrates an advanced platform with excellent physicochemical and biological properties for bone regeneration.

논문정보

형식Research article
게재일2024년 05월 (BRIC 등록일 2024-04-01)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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