한빛사논문
- 조회765
Hyo In Kim 1,7, Jinbong Park 2,7, Yin Zhu 3, Xiaoyun Wang 3, Yohan Han 3,4,5,* and Duo Zhang 3,6,*
1Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
2Department of Pharmacology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
3Clinical and Experimental Therapeutics, College of Pharmacy, University of Georgia and Charlie Norwood VA Medical Center, Augusta, GA 30912, USA.
4Department of Microbiology, Wonkwang University School of Medicine, Iksan 54538, Republic of Korea.
5Sarcopenia Total Solution Center, Wonkwang University, Iksan 54538, Republic of Korea.
6Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
7These authors contributed equally: Hyo In Kim, Jinbong Park.
*Corresponding authors: correspondence to Yohan Han or Duo Zhang
Abstract
Exosomes, which are nanosized vesicles secreted by cells, are attracting increasing interest in the field of biomedical research due to their unique properties, including biocompatibility, cargo loading capacity, and deep tissue penetration. They serve as natural signaling agents in intercellular communication, and their inherent ability to carry proteins, lipids, and nucleic acids endows them with remarkable therapeutic potential. Thus, exosomes can be exploited for diverse therapeutic applications, including chemotherapy, gene therapy, and photothermal therapy. Moreover, their capacity for homotypic targeting and self-recognition provides opportunities for personalized medicine. Despite their advantages as novel therapeutic agents, there are several challenges in optimizing cargo loading efficiency and structural stability and in defining exosome origins. Future research should include the development of large-scale, quality-controllable production methods, the refinement of drug loading strategies, and extensive in vivo studies and clinical trials. Despite the unresolved difficulties, the use of exosomes as efficient, stable, and safe therapeutic delivery systems is an interesting area in biomedical research. Therefore, this review describes exosomes and summarizes cutting-edge studies published in high-impact journals that have introduced novel or enhanced therapeutic effects using exosomes as a drug delivery system in the past 2 years. We provide an informative overview of the current state of exosome research, highlighting the unique properties and therapeutic applications of exosomes. We also emphasize challenges and future directions, underscoring the importance of addressing key issues in the field. With this review, we encourage researchers to further develop exosome-based drugs for clinical application, as such drugs may be among the most promising next-generation therapeutics.
논문정보
- Review Paper
- 2024년 04월 (BRIC 등록일 2024-04-01)
- 국내(교신)+국외 연구진
- 의약학 > 약학
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