권경하 (KAIST) | 한빛사논문 > 한빛사

한빛사논문

조회278

KAIST

CV File 154 kb

Proc. Natl. Acad. Sci. USA, Apr 02 2024, 121 (14) | https://doi.org/10.1073/pnas.2400868121 A wireless, implantable bioelectronic system for monitoring urinary bladder function following surgical recovery

Jihye Kim ^{# 1 2}, Matthew I Bury ^{# 3 4}, Kyeongha Kwon ^{# 5}, Jae-Young Yoo ^{1 6}, Nadia V Halstead ³, Hee-Sup Shin ¹, Shupeng Li ⁷, Sang Min Won ⁸, Min-Ho Seo ⁹, Yunyun Wu ¹, Do Yun Park ⁵, Mitali Kini ¹⁰, Jean Won Kwak ¹, Surabhi R Madhvapathy ¹, Joanna L Ciatti ¹, Jae Hee Lee ¹, Suyeon Kim ¹, Hanjun Ryu ^{1 11}, Kento Yamagishi ¹, Hong-Joon Yoon ^{1 12}, Sung Soo Kwak ^{1 13}, Bosung Kim¹, Yonggang Huang ^{1 7}, Lisa C Halliday ¹⁴, Earl Y Cheng ^{3 10}, Guillermo A Ameer ^{1 15 16 17 18 19 20 *}, Arun K Sharma^{3 4 10 15 16 21 *}, John A Rogers ^{1 7 15 16 17 18 19 20 22 23 *}

¹Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208.

²School of Advanced Materials Science and Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.

³Division of Pediatric Urology, Department of Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611.

⁴Stanley Manne Children's Research Institute, Louis A. Simpson and Kimberly K. Querrey Biomedical Research Center, Chicago, IL 60611.

⁵School of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.

⁶Department of Semiconductor Convergence Engineering, Sungkyunkwan University, Suwon 16417, Republic of Korea.

⁷Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208.

⁸Department of Electrical and Computer Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea.

⁹Department of Information Convergence Engineering, Pusan National University, Yangsan 50612, Republic of Korea.

¹⁰Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

¹¹Department of Advanced Materials Engineering, Chung-Ang University, Anseong 17546, Republic of Korea.

¹²Department of Electronic Engineering, Gachon University, Seongnam 13120, Republic of Korea.

¹³Bionics Research Center of Biomedical Research Division, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea.

¹⁴Biologic Resources Laboratory, University of Illinois at Chicago, Chicago, IL 60612.

¹⁵Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208.

¹⁶Center for Advanced Regenerative Engineering, Northwestern University, Evanston, IL 60208.

¹⁷Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

¹⁸Chemistry of Life Processes Institute, Northwestern University, Evanston, IL 60208.

¹⁹International Institute for Nanotechnology, Evanston, IL 60208.

²⁰Simpson Querrey Institute for Bionanotechnology, Evanston, IL 60208.

²¹Simpson Querrey Institute, Northwestern University, Chicago, IL 60611.

²²Department of Material Science and Engineering, Northwestern University, Evanston, IL 60208.

²³Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611.

^#Contributed equally.
^*Corresponding authors: correspondence to Guillermo A Ameer, Arun K Sharma or John A Rogers

Abstract

Partial cystectomy procedures for urinary bladder-related dysfunction involve long recovery periods, during which urodynamic studies (UDS) intermittently assess lower urinary tract function. However, UDS are not patient-friendly, they exhibit user-to-user variability, and they amount to snapshots in time, limiting the ability to collect continuous, longitudinal data. These procedures also pose the risk of catheter-associated urinary tract infections, which can progress to ascending pyelonephritis due to prolonged lower tract manipulation in high-risk patients. Here, we introduce a fully bladder-implantable platform that allows for continuous, real-time measurements of changes in mechanical strain associated with bladder filling and emptying via wireless telemetry, including a wireless bioresorbable strain gauge validated in a benchtop partial cystectomy model. We demonstrate that this system can reproducibly measure real-time changes in a rodent model up to 30 d postimplantation with minimal foreign body response. Studies in a nonhuman primate partial cystectomy model demonstrate concordance of pressure measurements up to 8 wk compared with traditional UDS. These results suggest that our system can be used as a suitable alternative to UDS for long-term postoperative bladder recovery monitoring.

논문정보

형식Research article
게재일2024년 04월 (BRIC 등록일 2024-03-29)
연구진국내+국외 연구진
분야 바이오·의료융합 > 의료기기

댓글 작성 로그인

CV 열람하기

연락처 보기