한빛사논문
- 조회387
Sang-Han Choi1, Geun Ho Im1, Sangcheon Choi2, Xin Yu2, Peter A. Bandettini3, Ravi S. Menon4, Seong-Gi Kim1,5*
1Center for Neuroscience Imaging Research, Institute for Basic Science, Suwon, Republic of Korea.
2Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, USA.
3Section on Functional Imaging Methods and Functional MRI Facility, NIMH, NIH, Bethesda, MD, USA.
4Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University, London, Ontario N6A 5B7, Canada.
5Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.
*Corresponding author : Seong-Gi Kim
Abstract
Direct imaging of neuronal activity (DIANA) by functional magnetic resonance imaging (fMRI) could be a revolutionary approach for advancing systems neuroscience research. To independently replicate this observation, we performed fMRI experiments in anesthetized mice. The blood oxygenation level-dependent (BOLD) response to whisker stimulation was reliably detected in the primary barrel cortex before and after DIANA experiments; however, no DIANA-like fMRI peak was observed in individual animals' data with the 50 to 300 trials. Extensively averaged data involving 1050 trials in six mice showed a flat baseline and no detectable neuronal activity-like fMRI peak. However, spurious, nonreplicable peaks were found when using a small number of trials, and artifactual peaks were detected when some outlier-like trials were excluded. Further, no detectable DIANA peak was observed in the BOLD-responding thalamus from the selected trials with the neuronal activity-like reference function in the barrel cortex. Thus, we were unable to replicate the previously reported results without data preselection.
- 관련 논문
Science, 13 Oct 2022, Vol 378, Issue 6616 pp. 160-168 | DOI: 10.1126/science.abh4340
In vivo direct imaging of neuronal activity at high temporospatial resolution
https://www.ibric.org/s.do?aSfezmZKQr
- 관련 기사 외
논문정보
- Research article
- 2024년 03월 (BRIC 등록일 2024-03-28)
- 국내(교신)+국외 연구진
- 생명과학 > 신경생물학
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