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Trends Endocrinol. Metab., Mar 25 2024, S1043-2760(24)00060-2 | https://doi.org/10.1016/j.tem.2024.02.017
Unveiling the cancer risk nexus of the steatotic liver
Jieun Kim 1, Ekihiro Seki 1,2
1Karsh Division of Gastroenterology and Hepatology, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA
Correspondence: Ekihiro Seki
Abstract
Steatotic liver, characterized by the accumulation of fat in the liver, poses significant health risks including metabolic dysfunction-associated steatotic liver disease (MASLD) and an elevated risk of primary liver cancer. Emerging evidence indicates a robust association between steatotic liver and increased susceptibility to extrahepatic primary cancers and their metastases. The deposition of fat induces dynamic changes in hepatic microenvironments, thereby fostering inflammation and immune responses that enhance liver metastasis from extrahepatic primary cancers. This review explores the impact of steatotic liver on hepatic carcinogenesis and metastasis from extrahepatic cancers, with a specific focus on hepatocyte-derived factors and the immune microenvironment. By emphasizing novel conclusions, this article underscores the timely relevance of understanding these intricate connections.
논문정보
- Review Paper
- 2024년 03월 (BRIC 등록일 2024-03-28)
- 국외 연구진
- 생명과학 > 분자생물학
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