Quan Truong Hoang (인천대학교) | 한빛사논문 > 한빛사

한빛사논문

조회305

인천대학교

Adv. Funct. Mater., First published: 14 January 2024 | https://doi.org/10.1002/adfm.202306078 Oxygen-Supplying Piezocatalytic Therapy of Hypoxic Tumors by Intratumoral Delivery of pH-Responsive Multicompartmental Carriers with Sequential Drug Release Capability

Quan Truong Hoang¹, Do Yeon Kim², Hyun Su Park³, Wookyoung Jang², Thuy Giang Nguyen Cao¹, Ji Hee Kang⁴, Young Tag Ko⁴, Seok Joon Mun², Suk Ho Bhang,^3* Min Suk Shim,^1* and Ki Wan Bong^2*

¹Department of Nano-Bioengineering, Incheon National University, Incheon, 22012 Republic of Korea

²Department of Chemical and Biological Engineering, Korea University, Seoul, 02841 Republic of Korea

³School of Chemical Engineering, Sungkyunkwan University, Suwon, 16419 Republic of Korea

⁴College of Pharmacy, Gachon University, Incheon, 21936 Republic of Korea

Q.T.H., D.Y.K., and H.S.P. contributed equally to this work.

CORRESPONDING AUTHORS : Suk Ho Bhang, Min Suk Shim, Ki Wan Bong

Abstract

Piezocatalytic cancer therapy, in which piezoelectric nanomaterials generate reactive oxygen species (ROS) via piezocatalytic redox reactions under mechanical stress, has emerged as an effective strategy for cancer treatment. However, the inherent hypoxia in tumor microenvironments enormously restricts its efficacy. To address this issue, acid-degradable Janus-type multicompartmental carriers able to separately encapsulate piezocatalytic gold nanoparticle-coated poly(ethylene glycol)-modified zinc oxide nanorods (Au@P-ZnO NRs) and O2-generating catalase (CAT) are fabricated in this study using stop-flow lithography (SFL). The CAT and Au@P-ZnO NRs are sequentially released by modulating the composition ratios of acid-cleavable monomers in the precursor solution during the SFL. The sequential release by the Janus carriers significantly increased the intracellular ROS levels under hypoxia conditions upon ultrasound irradiation owing to the O2 supplied by the CAT. An in vivo study showed that a single intratumoral injection of Janus particles encapsulating the CAT and Au@P-ZnO NRs efficiently alleviated tumor hypoxia and substantially suppressed tumor growth. This study demonstrates that pH-responsive, O2-generating, and piezocatalytic Janus carriers have high potential for piezocatalytic therapy of hypoxic tumors and offers insights into using pH-responsive Janus carriers for efficient hypoxia-relieving piezocatalytic cancer therapy via the cascade of oxygenation and ROS generation.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-03-27)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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