김시윤 (건국대학교 수의과대학) | 한빛사논문 > 한빛사

한빛사논문

조회303

건국대학교 수의과대학

CV File 115 kb

Adv. Sci., Mar 19 2024, | https://doi.org/10.1002/advs.202307353 Paintable Decellularized-ECM Hydrogel for Preventing Cardiac Tissue Damage

Jaewoo Lee ¹, Seul-Gi Lee², Beom-Seok Kim^3,4, Shinhye Park ², M Nivedhitha Sundaram ¹, Byung-Gee Kim ^4,5,6, C-Yoon Kim ⁷, Nathaniel S Hwang ^1,3,6

¹School of Chemical and Biological Engineering, Institute of Chemical Processes, Seoul National University, Seoul, 151-742, Republic of Korea.

²Department of Stem Cell Biology, School of Medicine, Konkuk University, Seoul, 143-701, Republic of Korea.

³Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, 151-742, Republic of Korea.

⁴Research Division, EGC Therapeutics, Seoul, 08790, Republic of Korea.

⁵Institute of Molecular Biology and Genetics, Institute for Sustainable Development (ISD), Seoul National University, Seoul, 08826, Republic of Korea.

⁶Bio-MAX/N-Bio, Institute of BioEngineering, Seoul National University, Seoul, 08826, Republic of Korea.

⁷College of Veterinary Medicine, Konkuk University, Seoul, 05029, Republic of Korea.

J.L. and S.-G.L. contributed equally to this work as the first author.

CORRESPONDING AUTHORS : C-Yoon Kim, Nathaniel S. Hwang

Abstract

The tissue-specific heart decellularized extracellular matrix (hdECM) demonstrates a variety of therapeutic advantages, including fibrosis reduction and angiogenesis. Consequently, recent research for myocardial infarction (MI) therapy has utilized hdECM with various delivery techniques, such as injection or patch implantation. In this study, a novel approach for hdECM delivery using a wet adhesive paintable hydrogel is proposed. The hdECM-containing paintable hydrogel (pdHA_t) is simply applied, with no theoretical limit to the size or shape, making it highly beneficial for scale-up. Additionally, pdHA_t exhibits robust adhesion to the epicardium, with a minimal swelling ratio and sufficient adhesion strength for MI treatment when applied to the rat MI model. Moreover, the adhesiveness of pdHA_t can be easily washed off to prevent undesired adhesion with nearby organs, such as the rib cages and lungs, which can result in stenosis. During the 28 days of in vivo analysis, the pdHA_t not only facilitates functional regeneration by reducing ventricular wall thinning but also promotes neo-vascularization in the MI region. In conclusion, the pdHA_t presents a promising strategy for MI treatment and cardiac tissue regeneration, offering the potential for improved patient outcomes and enhanced cardiac function post-MI.

논문정보

형식Research article
게재일2024년 03월 (BRIC 등록일 2024-03-20)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

댓글 작성 로그인

CV 열람하기

연락처 보기