박경순 (차의과학대학교)

한빛사논문

조회239

차의과학대학교

CV File 214 kb

J. Control. Release, Mar 16 2024, S0168-3659(24)00180-9 | https://doi.org/10.1016/j.jconrel.2024.03.027 Light emitting diode (LED) irradiation of liposomes enhances drug encapsulation and delivery for improved cancer eradication

Sujeong Lee ^a, Hye Jin Kim ^a, Jin-Ho Choi ^b, Hye Jung Jang^b, Hui Bang Cho ^a, Hye-Ryoung Kim ^a, Ji-in Park ^a, Kyung-soon Park^b, Keun-Hong Park ^a

^aLaboratory of Nano-regenerative Medicine, Department of Biomedical Science, College of Life Science, CHA University, CHA Biocomplex, Sampyeong-Dong, Bundang-gu, Seongnam-si 13488, Republic of Korea

^bDepartment of Biomedical Science, CHA University, Seongnam, Republic of Korea

Corresponding authors : Kyung-soon Park, Keun-Hong Park

Abstract

Liposomes are widely used as drug delivery nanoplatforms because of their versatility and biocompatibility; however, their ability to load certain drugs may be suboptimal. In this study, we generated liposomes using a combination of DSPE and DSPE-PEG-2 k lipids and loaded them with doxorubicin (DOX) and paclitaxel (PTX), to investigate the effects of light emitting diode (LED) irradiation on liposome structure and drug loading efficiency. Scanning and transmission electron microscopy revealed that the surface of liposomes irradiated with blue or near-infrared LEDs (LsLipo) was rougher and more irregular than that of non-LED-irradiated liposomes (NsLipo). Nuclear magnetic resonance analysis showed that the hydrogen peak originating from the lipid head groups was lower in LsLipo than in NsLipo preparations, indicating that LED irradiation changed the chemical and physical properties of the liposome. Structural changes, such as reduced rigidity, induced by LED irradiation, increased the loading efficiency of DOX and PTX. In vitro and in vivo experiments showed that LsLipo were more effective at inhibiting the growth of cancer cells than NsLipo. Our findings suggest that LED irradiation enhances the drug delivery efficacy of liposomes and offer new possibilities for improving drug delivery systems.

논문정보

형식Research article
게재일2024년 03월 (BRIC 등록일 2024-04-02)
연구진국내 연구진
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