손영옥 (제주대학교)

한빛사논문

조회344

제주대학교

CV File 633 kb

Ageing Res. Rev., Mar 15 2024, S1568-1637(24)00093-X | https://doi.org/10.1016/j.arr.2024.102275 Senolytic therapeutics: An emerging treatment modality for osteoarthritis

Md. Meraj Ansari ^a, Mrinmoy Ghosh ^a,b, Dong-Sun Lee ^c,d,e,f, Young-Ok Son ^a,c,d,f

^aDepartment of Animal Biotechnology, Faculty of Biotechnology, College of Applied Life Sciences Jeju National University, Jeju-si 63243, Republic of Korea

^bDepartment of Biotechnology, School of Bio, Chemical and Processing Engineering (SBCE), Kalasalingam Academy of Research and Education, Krishnankoil 626126, India

^cInterdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju-si 63243, Republic of Korea

^dBio-Health Materials Core-Facility Center, Jeju National University, Jeju-si 63243, Republic of Korea

^eFaculty of Biotechnology, College of Applied Life Sciences, Jeju National University, Jeju-si 63243, Republic of Korea

^fPractical Translational Research Center, Jeju National University, Jeju 63243, Republic of Korea

Corresponding authors : Dong-Sun Lee, Young-Ok Son

Abstract

Osteoarthritis (OA), a chronic joint disease affecting millions of people aged over 65 years, is the main musculoskeletal cause of diminished joint mobility in the elderly. It is characterized by lingering pain and increasing deterioration of articular cartilage. Aging and accumulation of senescent cells (SCs) in the joints are frequently associated with OA. Apoptosis resistance; irreversible cell cycle arrest; increased p16INK4a expression, secretion of senescence-associated secretory phenotype factors, senescence-associated β-galactosidase levels, secretion of extracellular vesicles, and levels of reactive oxygen and reactive nitrogen species; and mitochondrial dysregulation are some common changes in cellular senescence in joint tissues. Development of OA correlates with an increase in the density of SCs in joint tissues. Senescence-associated secretory phenotype has been linked to OA and cartilage breakdown. Senolytics and therapeutic pharmaceuticals are being focused upon for OA management. SCs can be selectively eliminated or killed by senolytics to halt the pathogenesis and progression of OA. Comprehensive understanding of how aging affects joint dysfunction will benefit OA patients. Here, we discuss age-related mechanisms associated with OA pathogenesis and senolytics as an emerging modality in the management of age-related SCs and pathogenesis of OA in preclinical and clinical studies.

논문정보

형식Review Paper
게재일2024년 03월 (BRIC 등록일 2024-03-19)
연구진국내(교신)+국외 연구진
분야 생명과학 > 세포생물학

댓글 작성 로그인

CV 열람하기

연락처 보기