박진영 (연세대학교)

한빛사논문

조회223

박진영Jin-Young Park

연세대학교

Nano Today, Volume 54, February 2024, 102120 | https://doi.org/10.1016/j.nantod.2023.102120 Dual-phase blocks for regeneration of critical-sized bone defects

Jiyu Kim^a,1, Sohyeon Park ^b,1, Jin-Young Park ^c,1, Ui-Won Jung ^c, Sungwon Jung ^a, Yoogyeong Oh ^a, Milae Lee ^a, Sung-eun Heo ^a, Bumgyu Choi ^a, Jae-Kook Cha ^c, Jinkee Hong ^a

^aDepartment of Chemical & Biomolecular Engineering, College of Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea

^bDepartment of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA

^cDepartment of Periodontology, Research Institute for Periodontal Regeneration, College of Dentistry, Yonsei University, Seoul, Republic of Korea

¹These authors contributed equally to this work.

Corresponding authors : Jae-Kook Cha, Jinkee Hong

Abstract

Repair of critical-size bone defects (CBD) remains a challenge in orthopedic surgery due to the restricted regenerative capacity of bone tissue. Herein, multi-functional biphasic calcium phosphate (BCP) blocks decorated with gelatin packs were developed for bone regeneration of CBDs. The gelatin packs consist of gelatin microspheres (GMSs) and an enzymatic crosslinked gelatin layer for bone morphogenetic protein-2 (BMP-2) and antibiotics delivery. The porous interior of the BCP block was filled with GMSs containing BMP-2 and tightly packed with an enzymatic crosslinked gelatin layer. The outermost part of the block was then covered with antibiotics-loaded GMSs. The BCP platform elaborately decorated for each zone improved the adhesion of osteoblasts and enabled the sequential release of antibiotics and BMP-2 and sustained release of BMP-2, realizing on-demand drug release according to the treatment stage. The programmed drug release of this platform significantly improved the regeneration of CBDs. In vivo experiments using dog's mandible defect models clearly demonstrated the clinical application potential of this BCP platform.

논문정보

형식Research article
게재일2024년 02월 (BRIC 등록일 2024-03-18)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오소재

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