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Trends Genet., Mar 13 2024, S0168-9525(24)00042-8 | https://doi.org/10.1016/j.tig.2024.02.006
PCNA cycling dynamics during DNA replication and repair in mammals
Sukhyun Kang 1, Juyeong Yoo 1,2, Kyungjae Myung 1,3
1Center for Genomic Integrity, Institute for Basic Science (IBS), Ulsan 44919, Republic of Korea
2Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea
3Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea
Correspondence: Kyungjae Myung
Abstract
Proliferating cell nuclear antigen (PCNA) is a eukaryotic replicative DNA clamp. Furthermore, DNA-loaded PCNA functions as a molecular hub during DNA replication and repair. PCNA forms a closed homotrimeric ring that encircles the DNA, and association and dissociation of PCNA from DNA are mediated by clamp-loader complexes. PCNA must be actively released from DNA after completion of its function. If it is not released, abnormal accumulation of PCNA on chromatin will interfere with DNA metabolism. ATAD5 containing replication factor C-like complex (RLC) is a PCNA-unloading clamp-loader complex. ATAD5 deficiency causes various DNA replication and repair problems, leading to genome instability. Here, we review recent progress regarding the understanding of the action mechanisms of PCNA unloading complex in DNA replication/repair pathways.
논문정보
- Review Paper
- 2024년 03월 (BRIC 등록일 2024-03-18)
- 국내 연구진
- 생명과학 > 분자생물학
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