한빛사논문
- 조회397
Anara Molkenova 1 †, Hye Eun Choi 1 †, Gibum Lee 2 †, Hayeon Baek 3, Mina Kwon 1, Su Bin Lee 1, Jeong-Min Park 4, Jae-Hyuk Kim 4, Dong-Wook Han 5, Jungwon Park 3, Sei Kwang Hahn 2 *, Ki Su Kim 1 *
1School of Chemical Engineering, Department of Organic Materials Science and Engineering, Institute for Advanced Organic Materials, Pusan National University, Busan, 46241, Republic of Korea.
2Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
3School of Chemical and Biological Engineering, College of Engineering, Seoul National University, Seoul, 08826, Republic of Korea.
4Department of Civil and Environmental Engineering, Pusan National University, Busan, 46241, Republic of Korea.
5Department of Cogno-Mechatronics Engineering, BIO-IT Fusion Technology Research Institute, Pusan National University, Busan, 46241, Republic of Korea.
†A.M., H.E.C., and G.L. contributed equally to this work.
*Corresponding authors: correspondence to Sei Kwang Hahn or Ki Su Kim
Abstract
Cryotherapy leverages controlled freezing temperature interventions to engender a cascade of tumor-suppressing effects. However, its bottleneck lies in the standalone ineffectiveness. A promising strategy is using nanoparticle therapeutics to augment the efficacy of cryotherapy. Here, a cold-responsive nanoplatform composed of upconversion nanoparticles coated with silica – chlorin e6 – hyaluronic acid (UCNPs@SiO2-Ce6-HA) is designed. This nanoplatform is employed to integrate cryotherapy with photodynamic therapy (PDT) in order to improve skin cancer treatment efficacy in a synergistic manner. The cryotherapy appeared to enhance the upconversion brightness by suppressing the thermal quenching. The low-temperature treatment afforded a 2.45-fold enhancement in the luminescence of UCNPs and a 3.15-fold increase in the photodynamic efficacy of UCNPs@SiO2-Ce6-HA nanoplatforms. Ex vivo tests with porcine skins and the subsequent validation in mouse tumor tissues revealed the effective HA-mediated transdermal delivery of designed nanoplatforms to deep tumor tissues. After transdermal delivery, in vivo photodynamic therapy using the UCNPs@SiO2-Ce6-HA nanoplatforms resulted in the optimized efficacy of 79% in combination with cryotherapy. These findings underscore the Cryo-PDT as a truly promising integrated treatment paradigm and warrant further exploring the synergistic interplay between cryotherapy and PDT with bright upconversion to unlock their full potential in cancer therapy.
논문정보
- Research article
- 2024년 03월 (BRIC 등록일 2024-03-15)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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