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Redox Biol., Mar 04 2024, 71 S2213-2317(24)00081-8 | https://doi.org/10.1016/j.redox.2024.103105
Development of dietary small molecules as multi-targeting treatment strategies for Alzheimer's disease
Rengasamy Balakrishnan a,b, Khoshnur Jannat b, Dong-Kug Choi a,b
aDepartment of Applied Life Sciences, Graduate School, BK21 Program, Konkuk University, Chungju, 27478, South Korea
bDepartment of Biotechnology, College of Biomedical and Health Science, Research Institute of Inflammatory Disease (RID), Konkuk University, Chungju, 27478, South Korea
Corresponding author : Dong-Kug Choi
Abstract
Cognitive dysfunction can occur both in normal aging and age-related neurological disorders, such as mild cognitive impairment and Alzheimer's disease (AD). These disorders have few treatment options due to side effects and limited efficacy. New approaches to slow cognitive decline are urgently needed. Dietary interventions (nutraceuticals) have received considerable attention because they exhibit strong neuroprotective properties and may help prevent or minimize AD symptoms. Biological aging is driven by a series of interrelated mechanisms, including oxidative stress, neuroinflammation, neuronal apoptosis, and autophagy, which function through various signaling pathways. Recent clinical and preclinical studies have shown that dietary small molecules derived from natural sources, including flavonoids, carotenoids, and polyphenolic acids, can modulate oxidative damage, cognitive impairments, mitochondrial dysfunction, neuroinflammation, neuronal apoptosis, autophagy dysregulation, and gut microbiota dysbiosis. This paper reviews research on different dietary small molecules and their bioactive constituents in the treatment of AD. Additionally, the chemical structure, effective dose, and specific molecular mechanisms of action are comprehensively explored. This paper also discusses the advantages of using nanotechnology-based drug delivery, which significantly enhances oral bioavailability, safety, and therapeutic effect, and lowers the risk of adverse effects. These agents have considerable potential as novel and safe therapeutic agents that can prevent and combat age-related AD.
논문정보
- Review Paper
- 2024년 03월 (BRIC 등록일 2024-03-13)
- 국내 연구진
- 생명과학 > 분자생물학
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