한빛사논문
- 조회197
Sung, Changhwan MD, PhD∗; Han, Sangwon MD, PhD∗; Yoon, Soyoon MD∗; Han, Shin Ae MD∗; Kang, Do-Yoon MD, PhD†,‡; Kim, Dae-Hee MD, PhD†,‡; Park, Duk-Woo MD, PhD†,‡; Song, Jong-Min MD, PhD†,‡; Lee, Jae Seung MD, PhD‡,§; Ryu, Jin-Sook MD, PhD∗; Moon, Dae Hyuk MD, PhD∗
From the ∗Department of Nuclear Medicine
†Division of Cardiology
‡Center for Pulmonary Hypertension and Venous Thrombosis
§Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Correspondence to: Sangwon Han, MD, PhD
Abstract
Purpose
The aim of this study was to assess the diagnostic performance of perfusion-only SPECT/CT (Q SPECT/CT) in comparison with that of ventilation/perfusion planar scintigraphy (V/Q planar), perfusion SPECT with ventilation scan (V/Q SPECT), and perfusion SPECT/CT with ventilation scan (V/Q SPECT/CT) in chronic thromboembolic pulmonary hypertension (CTEPH).
Patients and Methods
Patients with pulmonary hypertension who underwent ventilation-perfusion planar and SPECT/CT were retrospectively recruited. Two nuclear medicine physicians interpreted V/Q planar, V/Q SPECT, V/Q SPECT/CT, and Q SPECT/CT according to the European Association of Nuclear Medicine criteria. The diagnostic accuracy of these modalities for CTEPH was compared using a composite reference standard of pulmonary angiography, imaging test, cardiorespiratory assessment, and follow-up.
Results
A total of 192 patients were enrolled, including 85 with CTEPH. The sensitivity of Q SPECT/CT was 98.8%, which similar to that of V/Q planar (97.6%), V/Q SPECT (96.5%), or V/Q SPECT/CT (100.0%). In contrast, Q SPECT/CT exhibited significantly lower specificity (73.8%) compared with V/Q planar (86.9%, P = 0.001), V/Q SPECT (87.9%, P < 0.001), and V/Q SPECT/CT (88.8%, P < 0.001). The significantly lower specificity of Q SPECT/CT, compared with the 3 others, was observed in the subgroup aged ≥50 years (P < 0.001 for all), but not in those <50 years.
Conclusions
Q SPECT/CT exhibited lower specificity compared with V/Q planar, V/Q SPECT, and V/Q SPECT/CT in diagnosing CTEPH. It might underscore the essential role of a ventilation scan in patients with PH, even with the introduction of SPECT/CT.
논문정보
- Research article
- 2024년 03월 (BRIC 등록일 2024-03-26)
- 국내 연구진
- 의약학 > 신경의학
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