한빛사논문
- 조회437
Seung Wan Suh1†, Eunji Lim2†, Suh‑Yuhn Burm3, Hyungji Lee3, Jong Bin Bae3, Ji Won Han3 and Ki Woong Kim3,4,5*
1Seoul Heal Mental Health Clinic, Seoul, South Korea.
2Department of Psychiatry, Gyeongsang National University Changwon Hospital, Changwon, SouthKorea.
3Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea.
4Department of Psychiatry, Seoul National University, College of Medicine, Seoul, South Korea.
5Department of Brain and Cognitive Sciences, Seoul National University, College of Natural Sciences, Seoul, South Korea.
†Seung Wan Suh and Eunji Lim contributed equally to this work.
*Correspondence: Ki Woong Kim
Abstract
Background
Omega-3 polyunsaturated fatty acids (n-3 PUFA) have been suggested as a cognitive enhancing agent, though their effect is doubtful. We aimed to examine the effect of n-3 PUFA on the cognitive function of middle-aged or older adults without dementia.
Methods
We reviewed randomized controlled trials of individuals aged 40 years or older. We systematically searched PubMed/MEDLINE, EMBASE, CINAHL, PsycINFO, and Cochrane Library databases. We used the restricted cubic splines model for non-linear dose–response meta-analysis in terms of the standardized mean difference with 95% confidence intervals.
Results
The current meta-analysis on 24 studies (n 9660; follow-up 3 to 36 months) found that the beneficial effect on executive function demonstrates an upward trend within the initial 12 months of intervention. This effect is prominently observed with a daily intake surpassing 500 mg of n-3 PUFA and up to 420 mg of eicosapentaenoic acid (EPA). Furthermore, these trends exhibit heightened significance in regions where the levels of blood docosahexaenoic acid (DHA) + EPA are not very low.
Conclusions
Supplementation of n-3 PUFA may confer potential benefits to executive function among the middle-aged and elderly demographic, particularly in individuals whose dietary DHA + EPA level is not substantially diminished.
논문정보
- Research article
- 2024년 03월 (BRIC 등록일 2024-03-13)
- 국내 연구진
- 의약학 > 응용의학
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