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한빛사논문
- 조회544
ACS Nano, Mar 05 2024, 18 (9) | https://doi.org/10.1021/acsnano.3c09776
Highly Localized Chemical Sampling at Subsecond Temporal Resolution Enabled with a Silicon Nanodialysis Platform at Nanoliter per Minute Flows
Insu Park 1, Sungho Kim 1, Christopher Kenji Brenden 1, Weihua Shi 1, Hrishikesh Iyer 1, Rashid Bashir 1, Yurii Vlasov 1
1University of Illinois at Urbana-Champaign, Urbana, Illinois 61820, United States.
I.P. , S.K., and C.K.B. contributed equally to this work.
Corresponding Author : Yurii Vlasov
Abstract
Microdialysis (MD) is a versatile and powerful technique for chemical profiling of biological tissues and is widely used for quantification of neurotransmitters, neuropeptides, metabolites, biomarkers, and drugs in the central nervous system as well as in dermatology, ophthalmology, and pain research. However, MD performance is severely limited by fundamental tradeoffs between chemical sensitivity, spatial resolution, and temporal response. Here, by using wafer-scale silicon microfabrication, we develop and demonstrate a nanodialysis (ND) sampling probe that enables highly localized chemical sampling with 100 μm spatial resolution and subsecond temporal resolution at high recovery rates. These performance metrics, which are 100-1000× superior to existing MD approaches, are enabled by a 100× reduction of the microfluidic channel cross-section, a corresponding drastic 100× reduction of flow rates to exceedingly slow few nL/min flows, and integration of a nanometer-thin nanoporous membrane with high transport flux into the probe sampling area. Miniaturized ND probes may allow for the minimally invasive and highly localized sampling and chemical profiling in live biological tissues with high spatiotemporal resolution for clinical, biomedical, and pharmaceutical applications.
논문정보
- Research article
- 2024년 03월 (BRIC 등록일 2024-03-12)
- 국외 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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