한빛사논문
- 조회429
Seo Hee Choi 1, Byung min Lee 1†, Jina Kim 1, Do Young Kim 2, Jinsil Seong 1
1Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Republic of Korea
2Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
†Current address: Department of Radiation Oncology, Uijeongbu St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of Korea
Corresponding Author : Jinsil Seong
Abstract
Background & aims: Stereotactic ablative radiotherapy (SABR) has demonstrated curative potential with survival benefits in patients with oligometastatic disease (OMD). However, limited evidence exists regarding its use in oligometastatic hepatocellular carcinoma (HCC). We aimed to prospectively investigate the efficacy and safety of SABR in patients with oligometastatic HCC.
Methods: We enrolled patients with controlled primary HCC and one to five metastatic lesions amenable to SABR. The primary endpoint was treatment efficacy defined as overall survival (OS) and progression-free survival (PFS). The secondary endpoints included time to local progression, objective response rate, disease control rate, toxicities, and quality of life (QOL), assessed using the EORTC QLQ-C30 before, and 0, 1, and 3 months after SABR.
Results: Overall, 40 consecutive patients received SABR on 62 lesions between 2021 and 2022. The most common locations for OMD were the lungs (48.4%), lymph nodes (22.6%), and bone (17.7%). After a median follow-up of 15.5 months, the 2-year OS was 80%. Median PFS was 5.3 months, with 1- and 2-year rates of 21.2% and 0%, respectively. A shorter time to OMD from the controlled primary independently correlated with PFS (p=0.039, hazard ratio 2.127) alongside age, Child-Pugh class, and α-fetoprotein (p=0.002, 0.004, 0.019). The 2-year time to local progression, objective response rate, and disease control rate were 91.1%, 75.8%, and 98.4%, respectively. Overall, 10% of the patients experienced acute toxicity, and 7.5% experienced late toxicity, with no grade 3+ toxicity. All QOL scores remained stable, whereas the patients without systemic treatments had improved insomnia and social functioning scores.
Conclusions: SABR is an effective and feasible option for oligometastatic HCC, excellently controls local tumors, and improves survival without adversely affecting QOL.
논문정보
- Research article
- 2024년 03월 (BRIC 등록일 2024-03-12)
- 국내 연구진
- 의약학 > 응용의학
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