한빛사논문
- 조회375
Hyun-su Ha1#, Sewoom Baek2#, Kyubae Lee1,3#, Sungwoo Cho1, Min Jeong Cho4, Seyong Chung1, Hyeongyun Choi1, Chan Hee Lee1, Min Seok Kim1, Si Yeong Kim1, Dae-Hyun Kim5, Sang-Wook Kang6*, Hak-Joon Sung1,7*
1Department of Medical Engineering, Yonsei University College of Medicine, 50–1 Yonsei-ro, Seodaemun-gu, Seoul, 03722 Republic of Korea
2Department of Brain Korea 21 FOUR Project for Medical Science and Medical Engineering, Yonsei University College of Medicine, 50–1 Yonsei-ro, Seodaemun-gu, Seoul, 03722 Republic of Korea
3Department of Biomedical Materials, Konyang University, 158, Gwanjeodong-ro, Seo-gu, Daejeon, 35365 Republic of Korea
4Department of Clinical Pharmacology & Therapeutics, the Catholic University of Korea, Seoul St.Mary's Hospital, 222, BanpoDaero, Seocho-gu, Seoul, 06591 Republic of Korea
5Department of Veterinary Surgery, Chungnam National University College of Veterinary Medicine, 99, Daehak-ro, Yuseong-gu, Daejeon, 34134 Republic of Korea
6Department of Surgery, Yonsei University College of Medicine, Seoul, 03722 Republic of Korea
7Department of Brain Korea 21 FOUR Project for Medical Science and Medical Engineering, Yonsei University College of Medicine, 50–1 Yonsei-ro, Seodaemun-gu, Seoul, 03722 Republic of Korea
#H.-S.H., S.B., and K.L. contributed equally to this work.
*CORRESPONDING AUTHORS: Sang-Wook Kang, Hak-Joon Sung
Abstract
The control paradigm of small vessel pathophysiology has changed to focus on the vascular out-wall rather than the lumen-intimal factors. As an emerging controller of the external wall, the microvasculature (“vasa vasorum”) provides interactional routes between the in-and out-sides of the vascular wall. Despite numerous approaches to developing small-diameter vascular grafts, engineering artificial vasa vasorum (AVV) has not been projected as a multi-functional solution to address long-standing issues such as thrombotic and immune controls for wall regeneration. Here, the AVV is engineered using a microchannel network hydrogel after a multi-study validation of implantation functions and then used to wrap the external wall of the cell-free vessel post-decellularization while preserving its mechanical properties. Upon inter-positional and bypass grafting to rabbit arteries, the AVV graft facilitates the recruitment of vascular cells into the cell-free wall by promoting invasion of angiogenic and vasculogenic cells through the microchannel-mediated M2 polarization of macrophages. This function results in the efficient restoration of smooth muscle cells, and the revitalized vascular elasticity helps to maintain long-term patency. The AVV, therefore, serves as an effective catalyst for vascular wall regeneration, offering a solution to clinically successful small-diameter vascular grafting.
논문정보
- Research article
- 2024년 03월 (BRIC 등록일 2024-03-12)
- 국내 연구진
- 바이오·의료융합 > 바이오소재
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