한빛사논문
- 조회608
Min-Seok Rha1,2, Gyeongyeob Kim1,2, Sol Lee1,2, Chan Min Jung1, Young-Woo Lee1, Hae Eun Noh1, Yeonsu Jeong1, Hyung-Ju Cho1,3, Chang-Hoon Kim1,3
1Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea
2Department of Biomedical Sciences, Yonsei University College of Medicine, Seoul, Republic of Korea
3The Airway Mucus Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea
Correspondence: Chang-Hoon Kim and Min-Seok Rha
Abstract
T cells play pivotal roles in chronic rhinosinusitis (CRS) pathogenesis.1 Eosinophilic CRS (ECRS) is characterized by abundant T helper (Th) 2 cells that produce type 2 cytokines, while non-eosinophilic CRS (NECRS) features high frequencies of Th1 and/or Th17 cells.2 Tissue-resident memory T (TRM) cells are non-migrating memory T cells in non-lymphoid tissues, which act as cardinal sentinels against invading pathogens,3, 4 but may also play detrimental roles in chronic inflammatory diseases.5 Little is known about the phenotypes and functional roles of nasal TRM cells in CRS, and whether these cells' characteristics differ according to CRS endotype.
논문정보
- LETTER
- 2024년 03월 (BRIC 등록일 2024-03-11)
- 국내 연구진
- 의약학 > 면역의학
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