정원식 (KAIST)

한빛사논문

조회514

KAIST

CV File 280 kb

Adv. Mater., Mar 09 2024, | https://doi.org/10.1002/adma.202305830 Longitudinal Magnetic Resonance Imaging with ROS-Responsive Bilirubin Nanoparticles Enables Monitoring of Non-Alcoholic Steatohepatitis Progression to Cirrhosis

Wonsik Jung ¹, Muhammad Asaduddin ², Hyeongseop Keum ¹, Youngju Son ¹, Dohyun Yoo ¹, Dohyeon Kim ¹, Seojung Lee ¹, Dong Yun Lee ³, Jin Roh ⁴, Sung-Hong Park ², Sangyong Jon ¹

¹Department of Biological Sciences, Center for Precision Bio-Nanomedicine, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Daejeon, 34141, South Korea.

²Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Daejeon, 34141, South Korea.

³Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Seoul, 05505, South Korea.

⁴Department of Pathology, Ajou University School of Medicine, 164 Worldcup-ro, Suwon, 16499, South Korea.

W.J. and M.A. contributed equally to this work.

CORRESPONDING AUTHORS: Sung-Hong Park, Sangyong Jon

Abstract

Despite the vital importance of monitoring the progression of non-alcoholic fatty liver disease (NAFLD) and its progressive form, non-alcoholic steatohepatitis (NASH), we currently lack an efficient imaging modality that is readily available at hospitals. In this study, we present a new magnetic resonance imaging (MRI)-based imaging modality that allows for efficient and longitudinal monitoring of NAFLD and NASH progression. Our imaging modality uses manganese ion (Mn ²⁺ )-chelated bilirubin nanoparticles (Mn@BRNPs) as a reactive oxygen species (ROS)-responsive MRI imaging probe. We performed longitudinal T1-weighted MR imaging of NASH model mice after injecting Mn@BRNPs intravenously. The MR signal enhancement in the liver relative to muscle gradually increased up to 8 weeks of NASH progression, but decreased significantly as NASH progressed to the cirrhosis-like stage at weeks 10 and 12. We developed a new dual input pseudo three-compartment model to provide information on NASH stage with a single MRI scan. We also demonstrated that our ROS-responsive Mn@BRNPs can be used to monitor the efficacy of potential anti-NASH drugs with conventional MRI. Our findings suggest that our ROS-responsive Mn@BRNPs have the potential to serve as an efficient MRI contrast for monitoring NASH progression and its transition to the cirrhosis-like stage. This article is protected by copyright. All rights reserved.

논문정보

형식Research article
게재일2024년 03월 (BRIC 등록일 2024-03-11)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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