채한정 (전북대학교 약학대학)

한빛사논문

조회238

전북대학교 약학대학

CV File 39 kb

Ageing Res. Rev., Mar 07 2024, S1568-1637(24)00074-6 | https://doi.org/10.1016/j.arr.2024.102256 Aging Phenotype in AD Brain Organoids: Track to Success and Challenges

Muhammad Kamal Hossain ^a, Hyung-Ryong Kim ^b, Han Jung Chae^a

^aSchool of Pharmacy, Jeonbuk National University, Jeonju 54896, Republic of Korea

^bDepartment of Pharmacology, College of Dentistry, Jeonbuk National University, Jeonju 54896, Republic of Korea

Corresponding authors : Hyung-Ryong Kim, Han Jung Chae

Abstract

Alzheimer's disease (AD) poses a complex challenge, with abnormal protein accumulation in the brain causing memory loss and cognitive decline. Traditional models fall short in AD research, prompting interest in 3D brain organoids (BOs) from human stem cells. These findings hold promise for unveiling the mechanisms of AD, especially in relation to aging. However, an understanding of the aging impact of AD remains elusive. BOs offer insight but face challenges. This review delves into the role of BOs in deciphering aging-related AD and acknowledges limitations. Strategies to enhance BOs for accurate aging modeling in AD brains are suggested. Strengthened by molecular advancements, BOs have the potential to uncover the aging phenotype, advancing AD research.

논문정보

형식Review Paper
게재일2024년 03월 (BRIC 등록일 2024-03-11)
연구진국내 연구진
분야 의약학 > 약학

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