장예지 (서울대학교) | 한빛사논문 > 한빛사

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조회356

장예지Yeji Jang

서울대학교

Trends Endocrinol. Metab., Mar 06 2024, S1043-2760(24)00037-7 | https://doi.org/10.1016/j.tem.2024.02.008 Metabolic remodeling in cancer and senescence and its therapeutic implications

Yeonju Kim ^1,2,4, Yeji Jang^1,2,4, Mi-Sung Kim ^1,2, Chanhee Kang ^1,2,3

¹School of Biological Sciences, Seoul National University, Seoul 08826, South Korea

²Center for Systems Geroscience, Seoul National University, Seoul 08826, South Korea

³https://biosci.snu.ac.kr/kanglab

⁴These authors contributed equally to this work.

Correspondence: Chanhee Kang

Abstract

Cellular metabolism is a flexible and plastic network that often dictates physiological and pathological states of the cell, including differentiation, cancer, and aging. Recent advances in cancer metabolism represent a tremendous opportunity to treat cancer by targeting its altered metabolism. Interestingly, despite their stable growth arrest, senescent cells - a critical component of the aging process - undergo metabolic changes similar to cancer metabolism. A deeper understanding of the similarities and differences between these disparate pathological conditions will help identify which metabolic reprogramming is most relevant to the therapeutic liabilities of senescence. Here, we compare and contrast cancer and senescence metabolism and discuss how metabolic therapies can be established as a new modality of senotherapy for healthy aging.

논문정보

형식Review Paper
게재일2024년 03월 (BRIC 등록일 2024-03-08)
연구진국내 연구진
분야 생명과학 > 노화/암생물학

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