Apurva Jaiswal (광운대학교) | 한빛사논문 > 한빛사

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Apurva JaiswalApurva Jaiswal

광운대학교

Cancer Metastasis Rev., Mar 07 2024, | https://doi.org/10.1007/s10555-024-10175-w TFCP2 as a therapeutic nexus: unveiling molecular signatures in cancer

Neha Kaushik ^#,1, Apurva Jaiswal ^#,2, Pradeep Bhartiya¹, Eun Ha Choi², Nagendra Kumar Kaushik ²

¹Department of Biotechnology, College of Engineering, The University of Suwon, Hwaseong, 18323, Korea.

²Plasma Bioscience Research Center/Department of Electrical and Biological Physics, Kwangwoon University, Seoul, 01897, Korea.

^#Neha Kaushik and Apurva Jaiswal-these authors contributed equally.

Corresponding authors : Correspondence to Eun Ha Choi or Nagendra Kumar Kaushik.

Abstract

Tumor suppressor genes and proto-oncogenes comprise most of the complex genomic landscape associated with cancer, with a minimal number of genes exhibiting dual-context-dependent functions. The transcription factor cellular promoter 2 (TFCP2), a pivotal transcription factor encoded by the alpha globin transcription factor CP2 gene, is a constituent of the TFCP2/grainyhead family of transcription factors. While grainyhead members have been extensively studied for their crucial roles in developmental processes, embryogenesis, and multiple cancers, the TFCP2 subfamily has been relatively less explored. The molecular mechanisms underlying TFCP2's involvement in carcinogenesis are still unclear even though it is a desirable target for cancer treatment and a therapeutic marker. This comprehensive literature review summarizes the molecular functions of TFCP2, emphasizing its involvement in cancer pathophysiology, particularly in the epithelial-mesenchymal transition and metastasis. It highlights TFCP2's critical function as a regulatory target and explores its potential as a prognostic marker for survival and inflammation in carcinomas. Its ambiguous association with carcinomas underlines the urgent need for an in-depth understanding to facilitate the development of more efficacious targeted therapeutic modality and diagnostic tools. This study aims to elucidate the multifaceted effects of TFCP2 regulation, through a comprehensive integration of the existing knowledge in cancer therapeutics. Furthermore, the clinical relevance and the inherent challenges encountered in investigating its intricate role in cancer pathogenesis have been discussed in this review.

논문정보

형식Review Paper
게재일2024년 03월 (BRIC 등록일 2024-03-08)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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