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조회298

박세원Sewon Park

연세대학교

Adv. Drug Deliv. Rev., Mar 04 2024, S0169-409X(24)00060-7 | https://doi.org/10.1016/j.addr.2024.115238 Bioengineering toolkits for potentiating organoid therapeutics

Sewon Park ^a, Seung-Woo Cho^a,b,c

^aDepartment of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea

^bCenter for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, Republic of Korea

^cGraduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul 03722, Republic of Korea

Corresponding author : Seung-Woo Cho

Abstract

Organoids are three-dimensional, multicellular constructs that recapitulate the structural and functional features of specific organs. Because of these characteristics, organoids have been widely applied in biomedical research in recent decades. Remarkable advancements in organoid technology have positioned them as promising candidates for regenerative medicine. However, current organoids still have limitations, such as the absence of internal vasculature, limited functionality, and a small size that is not commensurate with that of actual organs. These limitations hinder their survival and regenerative effects after transplantation. Another significant concern is the reliance on mouse tumor-derived matrix in organoid culture, which is unsuitable for clinical translation due to its tumor origin and safety issues. Therefore, our aim is to describe engineering strategies and alternative biocompatible materials that can facilitate the practical applications of organoids in regenerative medicine. Furthermore, we highlight meaningful progress in organoid transplantation, with a particular emphasis on the functional restoration of various organs.

논문정보

형식Review Paper
게재일2024년 03월 (BRIC 등록일 2024-03-08)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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