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한정규Jeong-Kyu Han

한국과학기술연구원(KIST)

Nat. Commun., Mar 06 2024, 15 (1) | https://doi.org/10.1038/s41467-024-45803-0 Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation

Myeongki Cho^1,11, Jeong-Kyu Han^2,11, Jungmin Suh^1,11, Jeong Jin Kim³, Jae Ryun Ryu⁴, In Sik Min¹, Mingyu Sang¹, Selin Lim¹, Tae Soo Kim¹, Kyubeen Kim¹, Kyowon Kang¹, Kyuhyun Hwang⁵, Kanghwan Kim², Eun-Bin Hong⁶, Min-Ho Nam⁶, Jongbaeg Kim⁵, Young Min Song⁷, Gil Ju Lee³, Il-Joo Cho^8,9 & Ki Jun Yu^1,10

¹Functional Bio-integrated Electronics and Energy Management Lab, School of Electrical and Electronic Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.

²Brain Science Institute, Korea Institute of Science and Technology, 5. Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.

³Department of Electronics Engineering, Pusan National University, 2, Busandaehak-ro 63beon-gil, Geumjeong-gu, Busan 46241, Republic of Korea.

⁴Department of Anatomy, College of Medicine, Korea University, 17-gil Koryodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

⁵School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.

⁶Center for Brain Function, Korea Institute of Science and Technology 5, Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Republic of Korea.

⁷School of Electrical Engineering and Computer Science (EECS), Gwangju Institute of Science and Technology (GIST), Gwangju 61005, Republic of Korea.

⁸Department of Convergence Medicine, College of Medicine, Korea University, 17-gil Koryodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

⁹Department of Anatomy, College of Medicine, Korea University, 7-gil Koryodae-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.

¹⁰Department of Electrical and Electronic Engineering, YU-Korea Institute of Science and Technology (KIST) Institute, Yonsei University, 50, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea.

¹¹These authors contributed equally: Myeongki Cho, Jeong-Kyu Han, Jungmin Suh.

Corresponding authors : Correspondence to Gil Ju Lee, Il-Joo Cho or Ki Jun Yu.

Abstract

Bioresorbable neural implants based on emerging classes of biodegradable materials offer a promising solution to the challenges of secondary surgeries for removal of implanted devices required for existing neural implants. In this study, we introduce a fully bioresorbable flexible hybrid opto-electronic system for simultaneous electrophysiological recording and optogenetic stimulation. The flexible and soft device, composed of biodegradable materials, has a direct optical and electrical interface with the curved cerebral cortex surface while exhibiting excellent biocompatibility. Optimized to minimize light transmission losses and photoelectric artifact interference, the device was chronically implanted in the brain of transgenic mice and performed to photo-stimulate the somatosensory area while recording local field potentials. Thus, the presented hybrid neural implant system, comprising biodegradable materials, promises to provide monitoring and therapy modalities for versatile applications in biomedicine.

논문정보

형식Research article
게재일2024년 03월 (BRIC 등록일 2024-03-07)
연구진국내 연구진
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