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한빛사논문
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Trends Biochem. Sci., Feb 28 2024, S0968-0004(24)00023-9 | https://doi.org/10.1016/j.tibs.2024.01.008
Spray-type modifications: an emerging paradigm in post-translational modifications
Yun-Bin Lee 1, Hyun-Woo Rhee 1,2
1Department of Chemistry, Seoul National University, Seoul 08826, Korea
2School of Biological Sciences, Seoul National University, Seoul 08826, Korea
Correspondence: Hyun-Woo Rhee
Abstract
A post-translational modification (PTM) occurs when a nucleophilic residue (e.g., lysine of a target protein) attacks electrophilic substrate molecules (e.g., acyl-AMP), involving writer enzymes or even occurring spontaneously. Traditionally, this phenomenon was thought to be sequence specific; however, recent research suggests that PTMs can also occur in a non-sequence-specific manner confined to a specific location in a cell. In this Opinion, we compile the accumulated evidence of spray-type PTMs and propose a mechanism for this phenomenon based on the exposure level of reactive electrophilic substrate molecules at the active site of the PTM writers. Overall, a spray-type PTM conceptual framework is useful for comprehending the promiscuous PTM writer events that cannot be adequately explained by the traditional concept of sequence-dependent PTM events.
논문정보
- Review Paper
- 2024년 02월 (BRIC 등록일 2024-03-07)
- 국내 연구진
- 생명과학 > 세포생물학
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