한빛사논문
- 조회221
National Jewish Health
Evgeny Berdyshev PhDa,∗, Jihyun Kim MD, PhD c,d,∗, Byung Eui Kim MD, PhD b,∗, Elena Goleva PhD b, Taras Lyubchenko PhD b, Irina Bronova PhD a, Anna Sofia Bronoff BSc b, Olivia Xiao BSc b, Sehun Jang MD c, Sanghee Shin MD c, Jeongmin Song MD, PhD c, Jiwon Kim MD c, Sukyung Kim MD c, Boram Park PhD f, Kyunga Kim PhD f,g,h, Suk-Joo Choi MD, PhD i, Soo-Young Oh MD, PhD i, Kangmo Ahn MD, PhD c,d, Donald Y.M. Leung MD, PhD b
aDepartment of Medicine, National Jewish Health, Denver, USA
bDepartment of Pediatrics, National Jewish Health, Denver, USA
cDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
dDepartment of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences & Technology, Seoul, Korea
fBiomedical Statistics Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea
gDepartment of Digital Health, Samsung Advanced Institute for Health Sciences & Technology, Sungkyunkwan University, Seoul, Korea
hDepartment of Data Convergence & Future Medicine, Sungkyunkwan University School of Medicine, Seoul, Korea
iDepartment of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
∗These authors have contributed equally and are designated to have co-first authorship.
Corresponding Authors: Kangmo Ahn, MD, PhD, Donald YM Leung, MD, PhD
Abstract
Background: Food allergy (FA) often occurs in early childhood with and without atopic dermatitis (AD). FA can be severe and even fatal. For primary prevention, it is important to find early biomarkers to predict the future onset of FA before any clinical manifestations.
Objective: To find early predictors of future onset of FA in the stratum corneum (SC).
Methods: Skin tape strips (STS) were collected from the forearm of newborns (n=129) at the age of 2 months before any signs of clinical FA or AD. Children were clinically monitored until they reached 2 years of age to confirm the presence or absence of FA and AD. STS were subjected to lipidomic analyses by the LC-MS/MS and cytokine determination by Meso Scale Discovery U-Plex assay.
Results: Overall, 9/129 (7.0%) infants developed FA alone, and 9/129 (7.0%) infants developed FA concomitantly with AD (ADFA). In the SC of future FA and ADFA children, absolute amounts of unsaturated (N24:1)(C18S)Ceramide and (N26:1)(C18S)Ceramide and their relative percentages within the molecular group were increased in comparison to healthy children with p-values between <0.01 and p<0.05, ANOVA. Future AD children had normal levels of these molecules. Interleukin (IL)-33 was upregulated in future FA but not AD infants, whereas thymic stromal lymphopoietin (TSLP) was upregulated in AD but not FA. Logistic regression analysis revealed strong FA predicting power for the combination of dysregulated lipids and cytokines, with an odds ratio reaching 101.4 (95% CI 5.4 - 1910.6).
Conclusion: Non-invasive STS analysis at 2 months of age can identify infants at risk of future FA.
논문정보
- Research article
- 2024년 03월 (BRIC 등록일 2024-03-13)
- 국내(교신)+국외 연구진
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