이동성 (서울시립대학교)

한빛사논문

조회529

서울시립대학교

CV File 151 kb

Exp. Mol. Med., Mar 05 2024, | https://doi.org/10.1038/s12276-024-01186-2 Advances in single-cell omics and multiomics for high-resolution molecular profiling

Jongsu Lim^1,3, Chanho Park^1,3, Minjae Kim¹, Hyukhee Kim¹, Junil Kim² and Dong-Sung Lee¹

¹Department of Life Science, University of Seoul, Seoul 02504, Republic of Korea.

²School of Systems Biomedical Science, Soongsil University, Seoul 06978, Republic of Korea.

³These authors contributed equally: Jongsu Lim, Chanho Park.

Corresponding author : Correspondence to Dong-Sung Lee.

Abstract

Single-cell omics technologies have revolutionized molecular profiling by providing high-resolution insights into cellular heterogeneity and complexity. Traditional bulk omics approaches average signals from heterogeneous cell populations, thereby obscuring important cellular nuances. Single-cell omics studies enable the analysis of individual cells and reveal diverse cell types, dynamic cellular states, and rare cell populations. These techniques offer unprecedented resolution and sensitivity, enabling researchers to unravel the molecular landscape of individual cells. Furthermore, the integration of multimodal omics data within a single cell provides a comprehensive and holistic view of cellular processes. By combining multiple omics dimensions, multimodal omics approaches can facilitate the elucidation of complex cellular interactions, regulatory networks, and molecular mechanisms. This integrative approach enhances our understanding of cellular systems, from development to disease. This review provides an overview of the recent advances in single-cell and multimodal omics for high-resolution molecular profiling. We discuss the principles and methodologies for representatives of each omics method, highlighting the strengths and limitations of the different techniques. In addition, we present case studies demonstrating the applications of single-cell and multimodal omics in various fields, including developmental biology, neurobiology, cancer research, immunology, and precision medicine.

논문정보

형식Review Paper
게재일2024년 03월 (BRIC 등록일 2024-03-08)
연구진국내 연구진
분야 생명과학 > 유전학

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