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한빛사논문
- 조회333
Adv. Nutr., Jan 2024, 15 (1) S2161-8313(23)01397-2 | https://doi.org/10.1016/j.advnut.2023.10.008
Roles of Diet-Associated Gut Microbial Metabolites on Brain Health: Cell-to-Cell Interactions between Gut Bacteria and the Central Nervous System
Chong-Su Kim
Department of Food and Nutrition, College of Natural Information Sciences, Dongduk Women's University, Seoul 02748, Republic of Korea
Corresponding author : Chong-Su Kim
Abstract
Gut microbiota have crucial effects on brain function via the gut-brain axis. Growing evidence suggests that this interaction is mediated by signaling molecules derived from dietary components metabolized by the intestinal microbiota. Although recent studies have provided a substantial understanding of the cell-specific effects of gut microbial molecules in gut microbiome-brain research, further validation is needed. This review presents recent findings on gut microbiota-derived dietary metabolites that enter the systemic circulation and influence the cell-to-cell interactions between gut microbes and cells in the central nervous system (CNS), particularly microglia, astrocytes, and neuronal cells, ultimately affecting cognitive function, mood, and behavior. Specifically, this review highlights the roles of metabolites produced by the gut microbiota via dietary component transformation, including short-chain fatty acids, tryptophan metabolites, and bile acid metabolites, in promoting the function and maturation of brain cells and suppressing inflammatory signals in the CNS. We also discuss future directions for gut microbiome-brain research, focusing on diet-induced microbial metabolite-based therapies as possible novel approaches to mental health treatment.
논문정보
- Review Paper
- 2024년 01월 (BRIC 등록일 2024-03-12)
- 국내 연구진
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