한빛사논문
- 조회302
Min Seo Kim 1, Hyeon Jin Kim 2,3, So Min Kang 2, Young Mok Heo 4,5, Jiseung Kang 6,7, Tae Kyeong Ryu 2, Hyun Jeong Kim 2, Young-Bong Choi 8, Sol Kim 4,5, Youn Hwa Nho 4,5, Seunghyun Kang 4,5, Lee Smith 9, Ai Koyanagi 10, Nikolaos G Papadopoulos 11,12, Hyungwoo Jo 4,5, Dong-Geol Lee 4,5, Jung U Shin 13, Dong Keon Yon 2,3,14
1Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
2Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea.
3Department of Regulatory Science, Kyung Hee University, Seoul, South Korea.
4Research and Innovation Center, Cosmax BTI, Seoungnam, South Korea.
5Department of Microbiology, Dankook University, Cheonan, South Korea.
6Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
7Division of Sleep Medicine, Harvard Medical School, Boston, Massachusetts, USA.
8Department of Chemistry, Dankook University, Cheonan, South Korea.
9Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
10Research and Development Unit, Parc Sanitari Sant Joan de Deu, Barcelona, Spain.
11Allergy Department, 2nd Paediatric Clinic, National and Kapodistrian University of Athens, Athens, Greece.
12Division of Immunology, Immunity to Infection and Respiratory Medicine, Faculty or Biology, Medicine and Health, The University of Manchester, Manchester, UK.
13Department of Dermatology, CHA Bundang Medical Center, CHA University School of Medicine, Seongnam, South Korea.
14Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
Min Seo Kim, Hyeon Jin Kim, So Min Kang, Young Mok Heo, and Jiseung Kang contributed equally to this work.
Dong-Geol Lee, Jung U Shin, and Dong Keon Yon contributed equallyto this work.
Correspondence : Dong Keon Yon
Abstract
Atopic dermatitis (AD), a chronic inflammatory pruritic skin disorder, involves significant alternations in the skin microbiome compositions and reduction in filaggrin, a structural protein comprising epidermal barriers.1, 2 Previous research conducted highlighted the beneficial role of Streptococcus in enhancing skin elasticity, moisture contents, and the expression of filaggrin.3 Building upon these findings, we designed a proof-of-concept trial to evaluate the efficacy of a topical Streptococcus postbiotic emollient, specifically Strain CX, in 100 participants with mild-to-moderate AD. Our assessment encompassed clinical effects, laboratory parameters, and safety observations over 24 weeks.
논문정보
- Research article
- 2024년 03월 (BRIC 등록일 2024-03-05)
- 국내(교신)+국외 연구진
- 바이오·의료융합 > 다학제 융합/복합
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