Ivana Daubnerova (광주과학기술원) | 한빛사논문 > 한빛사

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Ivana DaubnerovaIvana Daubnerova

광주과학기술원

Proc. Natl. Acad. Sci. USA, Jan 26 2021, 118 (4) e2016878118 | https://doi.org/10.1073/pnas.2016878118 The neuropeptide allatostatin C from clock-associated DN1p neurons generates the circadian rhythm for oogenesis

Chen Zhang^a,1, Ivana Daubnerova^a,b,1, Yong-Hoon Jang^a, Shu Kondo^c, Dušan Žitnan^b, and Young-Joon Kim^a,2

^aSchool of Life Sciences, Gwangju Institute of Science and Technology, 61005 Gwangju, Republic of Korea;

^bInstitute of Zoology, Slovak Academy of Sciences, 84506 Bratislava, Slovakia; and

^cInvertebrate Genetics Laboratory, National Institute of Genetics, 411-8540 Shizuoka, Japan

¹C.Z. and I.D. contributed equally to this work.

²To whom correspondence may be addressed.

Abstract

The link between the biological clock and reproduction is evident in most metazoans. The fruit fly Drosophila melanogaster, a key model organism in the field of chronobiology because of its well-defined networks of molecular clock genes and pacemaker neurons in the brain, shows a pronounced diurnal rhythmicity in oogenesis. Still, it is unclear how the circadian clock generates this reproductive rhythm. A subset of the group of neurons designated "posterior dorsal neuron 1" (DN1p), which are among the ∼150 pacemaker neurons in the fly brain, produces the neuropeptide allatostatin C (AstC-DN1p). Here, we report that six pairs of AstC-DN1p send inhibitory inputs to the brain insulin-producing cells, which express two AstC receptors, star1 and AICR2. Consistent with the roles of insulin/insulin-like signaling in oogenesis, activation of AstC-DN1p suppresses oogenesis through the insulin-producing cells. We show evidence that AstC-DN1p activity plays a role in generating an oogenesis rhythm by regulating juvenile hormone and vitellogenesis indirectly via insulin/insulin-like signaling. AstC is orthologous to the vertebrate neuropeptide somatostatin (SST). Like AstC, SST inhibits gonadotrophin secretion indirectly through gonadotropin-releasing hormone neurons in the hypothalamus. The functional and structural conservation linking the AstC and SST systems suggest an ancient origin for the neural substrates that generate reproductive rhythms.

논문정보

형식Research article
게재일2021년 01월 (BRIC 등록일 2024-03-04)
연구진국내(교신)+국외 연구진
분야 생명과학 > 신경생물학

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