김주희 (한국과학기술연구원, Northwestern University)

한빛사논문

조회236

한국과학기술연구원, Northwestern University

CV File 128 kb

Biosens. Bioelectron., Feb 23 2024, 253 S0956-5663(24)00171-4 | https://doi.org/10.1016/j.bios.2024.116166 A skin-interfaced, miniaturized platform for triggered induction, capture and colorimetric multicomponent analysis of microliter volumes of sweat

Joohee Kim ^a,b,c,1, Seyong Oh^b,d,1, Da Som Yang ^b,1, Larissa Rugg ^e, Radhika Mathur ^e, Sung Soo Kwak ^a,b, Seonggwang Yoo ^b, Shupeng Li ^g, Evangelos E. Kanatzidis ^b, Geumbee Lee ^b, Hong-Joon Yoon ^b,f, Yonggang Huang^b,g, Roozbeh Ghaffari ^b,h,i, Susanna A. McColley ^e,j, John A. Rogers^b,g,h,i,k,l

^aCenter for Bionics of Biomedical Research Division, Korea Institute of Science and Technology, Seoul, 02792, Republic of Korea

^bQuerrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL, 60208, USA

^cPrecision Biology Research Center, Sungkyunkwan University, Suwon, 16419, Republic of Korea

^dDivision of Electrical Engineering, Hanyang University ERICA, Ansan, 15588, Republic of Korea

^eDivision of Pulmonary and Sleep Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, 60611, USA

^fDepartment of Electronic Engineering, Gachon University, Seongnam-si, Gyeonggi-do 13120, Republic of Korea

^gDepartment of Mechanical Engineering, Northwestern University, Evanston, IL, 60208, USA

^hDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, 60208, USA

ⁱEpicore Biosystems Inc., Cambridge, MA, 02139, USA

^jDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA

^kDepartment of Materials Science and Engineering, Northwestern University, Evanston, IL, 60208, USA

^lDepartment of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA

¹These authors contributed equally: Joohee Kim, Seyong Oh, and Da Som Yang.

Corresponding authors: Susanna A. McColley, John A. Rogers

Abstract

Eccrine sweat can serve as a source of biomarkers for assessing physiological health and nutritional balance, for tracking loss of essential species from the body and for evaluating exposure to hazardous substances. The growing interest in this relatively underexplored class of biofluid arises in part from its non-invasive ability for capture and analysis. The simplest devices, and the only ones that are commercially available, exploit soft microfluidic constructs and colorimetric assays with purely passive modes of operation. The most sophisticated platforms exploit batteries, electronic components and radio hardware for inducing sweat, for electrochemical evaluation of its content and for wireless transmission of this information. The work reported here introduces a technology that combines the advantages of these two different approaches, in the form of a cost-effective, easy-to-use device that supports on-demand evaluation of multiple biomarkers in sweat. This flexible, skin-interfaced, miniaturized system incorporates a hydrogel that contains an approved drug to activate eccrine sweat glands, electrodes and a simple circuit and battery to delivery this drug by iontophoresis through the surface of the skin, microfluidic channels and microreservoirs to capture the induced sweat, and multiple colorimetric assays to evaluate the concentrations of chloride, zinc, and iron. As demonstrated in healthy human participants monitored before and after a meal, such devices yield results that match those of traditional laboratory analysis techniques. Clinical studies that involve cystic fibrosis pediatric patients illustrate the use of this technology as a simple, painless, and reliable alternative to traditional hospital systems for measurements of sweat chloride.

논문정보

형식Research article
게재일2024년 02월 (BRIC 등록일 2024-03-11)
연구진국내+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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